The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

Endothelial cells play a wide variety of critical roles in the control of vascular function.
Indeed, since the early 1980s, the accumulating knowledge of the endothelial cell structure …

The coagulant and inflammatory exacerbation in sepsis is counterbalanced by the protective
protein C (PC) pathway. Activated PC (APC) was shown to use the endothelial cell PC …

The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …

TAFI (thrombin-activatable fibrinolysis inhibitor) is a recently discovered plasma protein that
can be activated by thrombin-catalyzed proteolysis to a carboxypeptidase B-like enzyme that …

Whereas unperturbed endothelial cells provide potent anticoagulant properties, exposure to
inflammatory and atherogenic stimuli can rapidly lead to a procoagulant behavior. Because …

Endothelial cells normally form a dynamically regulated barrier at the blood-tissue interface,
and breakdown of this barrier is a key pathogenic factor in inflammatory disorders such as …

During embryonic development, endothelial cells differentiate from a common precursor
called angioblast and acquire organ-specific properties. One of the important determinants …

The flow-responsive transcription factor KLF2 is acquiring a leading role in the regulation of
endothelial cell gene expression. A genome-wide microarray expression profiling is …