Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Fungal pathogens of the Cryptococcus neoformans species complex (C. neoformans SC)
are a major cause of fungal meningitis in immunocompromised individuals. As with other …

Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is
an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and …

Cryptococcus neoformans is a facultative intracellular fungal pathogen. Ten-generation-old
(10GEN) C. neoformans cells are more resistant to phagocytosis and killing by …

The importance of fungal infections, particularly those caused by yeasts, is increasing
among the medical community. Candida albicans and Cryptococcus neoformans are …

Data about the relationship between their molecular types, virulence factors, clinical
presentation, antifungal susceptibility profile, and outcome are still limited for Cryptococcus …

Many fungi produce melanins, which can play critical roles in virulence and pathogenicity. In
fungal pathogenic species, melanin confers protection against host immune defense …

Urease and phospholipase are enzymes that are important virulence factors for
Cryptococcus neoformans. These are two of the most studied enzymes involved in how C …

Members of the fungal kingdom make many types or classes of melanins. Most fungal
species produce melanins of the allomelanin or eumelanin classes, canonically from the …