Research progress on the synthesis and pharmacology of 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole derivatives: a mini review

JJ Wang, W Sun, WD Jia, M Bian… - Journal of Enzyme …, 2022 - Taylor & Francis
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …

Synthesis, biological evaluation, and molecular docking studies of novel diclofenac derivatives as antibacterial agents

MM Hamed, M Sayed, SA Abdel-Mohsen… - Journal of Molecular …, 2023 - Elsevier
In the recent years, interest in the synthesis of diclofenac derivatives has increased due to
their exceptional biological activity. We present here the synthesis of some novel diclofenac …

Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with thieno [2, 3-d] pyrimidine substitution

R Ding, X Wang, J Fu, Y Chang, Y Li, Y Liu… - European Journal of …, 2022 - Elsevier
A series of novel pleuromutilin derivatives with substituted thienopyrimidines were designed,
synthesized, and evaluated for antibacterial act ivity. In this study, the activities of these …

Solid-state luminescent materials containing both indole and pyrimidine moieties: Design, synthesis, and density functional theory calculations

O Younis, M Sayed, AAK Mohammed, MS Tolba… - ACS …, 2022 - ACS Publications
Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It
has been observed that combining pyrimidine and indole moieties in a single molecule can …

Synthesis and intriguing single-component white-light emission from oxadiazole or thiadiazole integrated with coumarin luminescent core

O Younis, AF Al-Hossainy, M Sayed… - … of Photochemistry and …, 2022 - Elsevier
There has been evidence of non-typical fluorescence activities in thiadiazole and
oxadiazole derivatives. Also, some coumarin compounds with tunable luminescence …

From blue to green photoluminescence: Design, synthesis, and DFT calculations of heterocyclic compounds containing chromenothienopyrimidine moiety

MS Tolba, AF Al‐Hossainy… - Asian Journal of …, 2022 - Wiley Online Library
Incorporating coumarin nuclei into other heterocyclic scaffolds such as thienopyrimidine can
significantly increase the photophysical and biological efficiency. Accordingly, we describe …

[HTML][HTML] Green synthesis of some tetrahydroquinoline derivatives and evaluation as anticancer agents

NMM Alanazi, IO Althobaiti, YA El-Ossaily… - Arabian Journal of …, 2023 - Elsevier
This study demonstrates the design and synthesis of heterocyclic compounds with diverse
biological effects. Using an ionic liquid catalyst, a sonosynthetic approach for the assembly …

Fused Thienopyrimidines as Versatile Pharmacophores for the Development of Cyclooxygenase‐2 Inhibitors

S Thakur, S Arora, MK Katiyar, G Joshi… - …, 2024 - Wiley Online Library
Inflammation is an essential body immune system response against various infections and
tissue injuries and maintains normal homeostasis. Alterations in inflammatory responses …

Synthesis, computational drug likeness, DFT studies and in vitro biological activity evaluation of some heteronuclear complexes of functionalized (E)‐2‐(butan‐2 …

T Khan, I Azad, R Ahmad, S Raza… - Vietnam Journal of …, 2023 - Wiley Online Library
The dinuclear complexes of Schiff bases possess interesting structures and activity
spectrum. Five mixed metal complexes of 2‐butanone thiosemicarbazone were prepared …

Antimicrobial Evaluation of Sulfonamides after Coupling with Thienopyrimidine Coplanar Structure

EI Elmongy, WS Alanazi, AI Aldawsari, AA Alfaouri… - Pharmaceuticals, 2024 - mdpi.com
This work describes the design and synthesis of three series of hybrids of thienopyrimidines
and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico …