Distinct influence of COX-1 and COX-2 on neuroinflammatory response and associated cognitive deficits during high altitude hypoxia
High-altitude hypoxia (HH) causes a spectrum of pathophysiological effects, including
headaches, gliovascular dysfunction, and cognitive slowing. Previous studies have shown …
headaches, gliovascular dysfunction, and cognitive slowing. Previous studies have shown …
Erythropoietin ameliorates neonatal hypoxia-ischemia-induced neurobehavioral deficits, neuroinflammation, and hippocampal injury in the juvenile rat
KM Lan, LT Tien, Z Cai, S Lin, Y Pang… - International journal of …, 2016 - mdpi.com
The hematopoietic growth factor erythropoietin (EPO) has been shown to be neuroprotective
against hypoxia-ischemia (HI) in Postnatal Day 7 (P7)–P10 or adult animal models. The …
against hypoxia-ischemia (HI) in Postnatal Day 7 (P7)–P10 or adult animal models. The …
Systemic lipopolysaccharide-induced pain sensitivity and spinal inflammation were reduced by minocycline in neonatal rats
In this study, we investigated the effects of minocycline, a putative suppressor of microglial
activation, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation …
activation, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation …
[HTML][HTML] Using Caenorhabditis elegans to model therapeutic interventions of neurodegenerative diseases targeting microbe-host interactions
Emerging evidence from both clinical studies and animal models indicates the importance of
the interaction between the gut microbiome and the brain in the pathogenesis of …
the interaction between the gut microbiome and the brain in the pathogenesis of …
Targeting abnormal PI3K/AKT/mTOR signaling in intracerebral hemorrhage: A systematic review on potential drug targets and influences of signaling modulators on …
KS Jadaun, A Sharma, EM Siddiqui… - Current Reviews in …, 2022 - ingentaconnect.com
PI3K/AKT/mTOR (phosphoinositide 3-kinase/protein kinase B/mammalian target of
rapamycin) signaling pathway is an important signal transduction pathway mediated by …
rapamycin) signaling pathway is an important signal transduction pathway mediated by …
Virgin coconut oil-induced neuroprotection in lipopolysaccharide-challenged rats is mediated, in part, through cholinergic, anti-oxidative and anti-inflammatory …
Neuroinflammation is associated with neuronal cell death and could lead to chronic
neurodegeneration. This study investigated the neuroprotective potential of virgin coconut …
neurodegeneration. This study investigated the neuroprotective potential of virgin coconut …
Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal …
Perinatal inflammation-induced reduction in pain threshold may alter pain sensitivity to
hyperalgesia or allodynia which may persist into adulthood. In this study, we investigated the …
hyperalgesia or allodynia which may persist into adulthood. In this study, we investigated the …
Studies on 16, 17-pyrazoline substituted heterosteroids as anti-Alzheimer and anti-Parkinsonian agents using LPS induced neuroinflammation models of mice and …
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common forms of
neurodegenerative disorders. Dehydroepiandrosterone (DHEA) has been reported as a …
neurodegenerative disorders. Dehydroepiandrosterone (DHEA) has been reported as a …
Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of mania
SS Valvassori, GC Dal-Pont, PT Tonin… - Pharmacology …, 2019 - Elsevier
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on
inflammatory parameters in an animal model of mania induced by dextroamphetamine (D …
inflammatory parameters in an animal model of mania induced by dextroamphetamine (D …
Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood
MT Gervasi, R Romero, E Cainelli… - Journal of Perinatal …, 2023 - degruyter.com
Objectives Intra-amniotic inflammation is a subclinical condition frequently caused by either
microbial invasion of the amniotic cavity or sterile inflammatory stimuli, eg, alarmins. An …
microbial invasion of the amniotic cavity or sterile inflammatory stimuli, eg, alarmins. An …