[HTML][HTML] Novel insights into the roles of Rho kinase in cancer
L Wei, M Surma, S Shi, N Lambert-Cheatham… - Archivum immunologiae …, 2016 - Springer
Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …
Viscoelasticity in natural tissues and engineered scaffolds for tissue reconstruction
Viscoelasticity of living tissues plays a critical role in tissue homeostasis and regeneration,
and its implication in disease development and progression is being recognized recently. In …
and its implication in disease development and progression is being recognized recently. In …
FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer
Abstract Purpose: The aberrantly upregulated Friend leukemia virus integration 1 (FLI1) is
closely correlated with the malignant phenotype of small cell lung cancer (SCLC). It is …
closely correlated with the malignant phenotype of small cell lung cancer (SCLC). It is …
Rho kinases in health and disease: from basic science to translational research
G Loirand - Pharmacological reviews, 2015 - ASPET
Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …
dynamics downstream of Rho GTPases that participate in the control of important …
Rho-kinase: regulation,(dys) function, and inhibition
In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …
Interphase phosphorylation of lamin A
V Kochin, T Shimi, E Torvaldson… - Journal of cell …, 2014 - journals.biologists.com
Nuclear lamins form the major structural elements that comprise the nuclear lamina. Loss of
nuclear structural integrity has been implicated as a key factor in the lamin A/C gene …
nuclear structural integrity has been implicated as a key factor in the lamin A/C gene …
[HTML][HTML] Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells
Long non-coding RNAs (lncRNAs) are involved in various biological processes and
diseases including osteosarcoma. Long non-coding RNA metastasis-associated lung …
diseases including osteosarcoma. Long non-coding RNA metastasis-associated lung …
[HTML][HTML] miR-335-5p inhibits TGF-β1-induced epithelial–mesenchymal transition in non-small cell lung cancer via ROCK1
W Du, H Tang, Z Lei, J Zhu, Y Zeng, Z Liu, J Huang - Respiratory research, 2019 - Springer
Background Significant evidence has shown that the miRNA pathway is an important
component in the downstream signaling cascades of TGF-β1 pathway. Our previous study …
component in the downstream signaling cascades of TGF-β1 pathway. Our previous study …
[PDF][PDF] Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes
Adipose tissue is an essential regulator of metabolic homeostasis. In contrast with white
adipose tissue, which stores excess energy in the form of triglycerides, brown adipose tissue …
adipose tissue, which stores excess energy in the form of triglycerides, brown adipose tissue …
RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeleton
L Tang, F Dai, Y Liu, X Yu, C Huang, Y Wang… - Pharmacological …, 2018 - Elsevier
The RhoA/ROCK signaling pathway regulates cell morphology, adhesion, proliferation, and
migration. In this study, we investigated the regulatory role of RhoA/ROCK signaling on …
migration. In this study, we investigated the regulatory role of RhoA/ROCK signaling on …