Microglial Piezo1 mechanosensitive channel as a therapeutic target in Alzheimer's disease
Microglia are the resident macrophages of the central nervous system (CNS) that control
brain development, maintain neural environments, respond to injuries, and regulate …
brain development, maintain neural environments, respond to injuries, and regulate …
Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity
BP Hurrell, S Shen, X Li, Y Sakano… - Journal of Experimental …, 2024 - rupress.org
Mechanosensitive ion channels sense force and pressure in immune cells to drive the
inflammatory response in highly mechanical organs. Here, we report that Piezo1 channels …
inflammatory response in highly mechanical organs. Here, we report that Piezo1 channels …
Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors
Y Zhang, W Zou, W Dou, H Luo, X Ouyang - Frontiers in Physiology, 2024 - frontiersin.org
Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein.
Piezo1 has various effects and plays an important and irreplaceable role in the maintenance …
Piezo1 has various effects and plays an important and irreplaceable role in the maintenance …
Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury
M Zhang, QR Wang, X Hou, Q Wang, X Yang, T Zhou… - Parasites & …, 2024 - Springer
Background Malaria-associated acute lung injury (MA-ALI) is a well-recognized clinical
complication of severe, complicated malaria that is partly driven by sequestrations of …
complication of severe, complicated malaria that is partly driven by sequestrations of …
Piezo1 stretch‐activated channel activity differs between murine bone marrow‐derived and cardiac tissue‐resident macrophages
A Simon‐Chica, A Klesen, R Emig… - The Journal of …, 2024 - Wiley Online Library
Macrophages (MΦ) play pivotal roles in tissue homeostasis and repair. Their mechanical
environment has been identified as a key modulator of various cell functions, and MΦ …
environment has been identified as a key modulator of various cell functions, and MΦ …
Piezo1 mediates abnormal type 2 immune response to aggravate ischemia–reperfusion acute lung injury which by regulating alveolar macrophages derived IL-33: A …
L XiWang, W XueKe, P YiHang, Y LiYang, X WeiZe… - Medical …, 2024 - Elsevier
The pathogenesis of ischemia–reperfusion acute lung injury (IR-ALI) is not yet fully
understood. We previously reported that unwonted increased type 2 immunity plays a key …
understood. We previously reported that unwonted increased type 2 immunity plays a key …