Oxidative stress and cellular response to doxorubicin: a common factor in the complex milieu of anthracycline cardiotoxicity
D Cappetta, A De Angelis, L Sapio… - Oxidative medicine …, 2017 - Wiley Online Library
The production of reactive species is a core of the redox cycling profile of anthracyclines.
However, these molecular characteristics can be viewed as a double‐edged sword acting …
However, these molecular characteristics can be viewed as a double‐edged sword acting …
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
C Szabó, H Ischiropoulos, R Radi - Nature reviews Drug discovery, 2007 - nature.com
Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …
A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on …
Executive summary Elevated blood pressure is the strongest modifiable risk factor for
cardiovascular disease worldwide. Despite extensive knowledge about ways to prevent as …
cardiovascular disease worldwide. Despite extensive knowledge about ways to prevent as …
Protective effects of nebivolol against anthracycline-induced cardiomyopathy: a randomized control study
Background We aimed to evaluate the effect of prophylactic nebivolol use on prevention of
antracycline-induced cardiotoxicity in breast cancer patients. Methods In this small …
antracycline-induced cardiotoxicity in breast cancer patients. Methods In this small …
Doxorubicin targets multiple players: a new view of an old problem
Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer
survivors, and the advancement of cardio-oncology is a necessary step for an effective care …
survivors, and the advancement of cardio-oncology is a necessary step for an effective care …
[HTML][HTML] Omega-3 and omega-6 fatty acids have distinct effects on endothelial fatty acid content and nitric oxide bioavailability
SCR Sherratt, H Dawoud, DL Bhatt, T Malinski… - … and Essential Fatty …, 2021 - Elsevier
Abstract Treatment with high dose icosapent ethyl (IPE), an ethyl ester of the omega-3 fatty
acid eicosapentaenoic acid (EPA), significantly reduced ischemic events in patients with …
acid eicosapentaenoic acid (EPA), significantly reduced ischemic events in patients with …
Biochemistry of protein tyrosine nitration in cardiovascular pathology
G Peluffo, R Radi - Cardiovascular research, 2007 - academic.oup.com
Several pathologies of the cardiovascular system are associated with an augmented
production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the …
production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the …
Nebivolol: the somewhat-different β-adrenergic receptor blocker
Although its clinical use in Europe dates almost 10 years, nebivolol is a β-blocker that has
been only recently introduced in the US market. Like carvedilol, nebivolol belongs to the …
been only recently introduced in the US market. Like carvedilol, nebivolol belongs to the …
Leptin-induced endothelial dysfunction in obesity
Hyperleptinemia accompanying obesity affects endothelial nitric oxide (NO) and is a serious
factor for vascular disorders. NO, superoxide (O2−), and peroxynitrite (ONOO−) nanosensors …
factor for vascular disorders. NO, superoxide (O2−), and peroxynitrite (ONOO−) nanosensors …
NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition
S Selemidis, CG Sobey, K Wingler… - Pharmacology & …, 2008 - Elsevier
Until the 1970s, reactive oxygen species (ROS) were considered merely harmful by-
products of aerobic respiration and the driving force behind the evolution of an array of …
products of aerobic respiration and the driving force behind the evolution of an array of …