Protein tyrosine nitration in atherosclerotic endothelial dysfunction

M Jiang, XM Zhao, ZS Jiang, GX Wang, D Zhang - Clinica Chimica Acta, 2022 - Elsevier
Accumulation of reactive oxygen species (ROS) can induce both protein tyrosine nitration
and endothelial dysfunction in atherosclerosis. Endothelial dysfunction refers to impaired …

c-Jun N-Terminal Kinase 2 Deficiency Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction and Oxidative Stress

E Osto, CM Matter, A Kouroedov, T Malinski… - Circulation, 2008 - Am Heart Assoc
Background—Hypercholesterolemia-induced endothelial dysfunction due to excessive
production of reactive oxygen species is a major trigger of atherogenesis. The c-Jun-N …

Compositions and methods for treating or preventing obesity in a subject in need thereof

JS Zakrzewski - US Patent 10,206,898, 2019 - Google Patents
5, 656, 667 A 5, 698, 594 A 5, 760, 081 A 5, 763, 496 A 5, 776, 978 A 5, 792, 795 A 5, 837,
731 A 5, 840, 944 A 5, 886, 037 A 5, 888, 541 A 5, 948, 818 A 6, 025, 008 A 6, 069, 168 A 6 …

Methods of reducing apolipoprotein C-III

M Manku, I Osterloh, P Wicker, R Braeckman… - US Patent …, 2019 - Google Patents
US10166209B2 - Methods of reducing apolipoprotein C-III - Google Patents
US10166209B2 - Methods of reducing apolipoprotein C-III - Google Patents Methods of …

Methods of treating mixed dyslipidemia

I Osterloh, P Wicker, R Braeckman, P Soni… - US Patent …, 2018 - Google Patents
US9855237B2 - Methods of treating mixed dyslipidemia - Google Patents US9855237B2 -
Methods of treating mixed dyslipidemia - Google Patents Methods of treating mixed dyslipidemia …

NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys

S Joshi, AB Peck, SR Khan - Oxidative medicine and cellular …, 2013 - Wiley Online Library
A major role of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of
enzymes is to catalyze the production of superoxides and other reactive oxygen species …

Methods of treating hypertriglyceridemia

M Manku, I Osterloh, P Wicker, R Braeckman… - US Patent …, 2020 - Google Patents
5,760,081 A 5,763,496 A 5,776,978 A 5,792,795 A 5,837,731 A 5,840,944 A 5,886,037 A
5,888,541 A 5,948,818 A 6,025,008 A 6,069,168 A 6,193,999 B1 6,284,268 B1 6,313,330 …

Methods of reducing RLP-C

I Osterloh, P Wicker, R Braeckman, P Soni… - US Patent …, 2020 - Google Patents
In various embodiments, the present invention provides methods of treating and/or
preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy …

Updates on pharmacologic management of microvascular angina

M Soleymani, F Masoudkabir… - Cardiovascular …, 2022 - Wiley Online Library
Microvascular angina (MVA), historically called cardiac syndrome X, refers to angina with
nonobstructive coronary artery disease. This female‐predominant cardiovascular disorder …

Pharmaceutical compositions comprising omega-3 fatty acids

M Manku, J Rowe - US Patent 10,888,537, 2021 - Google Patents
The present disclosure relates to, inter alia, pharmaceutical compositions comprising omega-
3 fatty acids.