[HTML][HTML] Protein cargo in extracellular vesicles as the key mediator in the progression of cancer
K Hánělová, M Raudenská, M Masařík… - Cell Communication and …, 2024 - Springer
Exosomes are small vesicles of endosomal origin that are released by almost all cell types,
even those that are pathologically altered. Exosomes widely participate in cell-to-cell …
even those that are pathologically altered. Exosomes widely participate in cell-to-cell …
ER: a critical hub for STING signaling regulation
Abstract The Stimulator of Interferon Genes (STING) has a crucial role in mediating the
immune response against cytosolic double-stranded DNA (dsDNA) and its activation is …
immune response against cytosolic double-stranded DNA (dsDNA) and its activation is …
[HTML][HTML] Tumor cells transmit drug resistance via cisplatin-induced extracellular vesicles
J Wang, Q Liu, Y Zhao, J Fu, J Su - International Journal of Molecular …, 2023 - mdpi.com
Cisplatin is a first-line clinical agent used for treating solid tumors. Cisplatin damages the
DNA of tumor cells and induces the production of high levels of reactive oxygen species to …
DNA of tumor cells and induces the production of high levels of reactive oxygen species to …
Interferon induction by STING requires its translocation to the late endosomes
To combat microbial infections, mammalian cells use a variety of innate immune response
pathways to induce synthesis of anti‐microbial proteins. The cGAS/STING pathway …
pathways to induce synthesis of anti‐microbial proteins. The cGAS/STING pathway …
Chemical Biology perspectives on STING agonists as Tumor Immunotherapy
C Xuan, R Hu - ChemMedChem, 2023 - Wiley Online Library
Stimulator of interferon genes (STING) is a crucial adaptor protein in the innate immune
response. STING activation triggers cytokine secretion, including type I interferon and …
response. STING activation triggers cytokine secretion, including type I interferon and …
[HTML][HTML] A sequential scheme including PTT and 2′ 3′-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway
X Song, M Wang, S Liu, H Liu, A Jiang, Y Zou… - Pharmacological …, 2023 - Elsevier
Photothermal therapy (PTT) is a promising antitumor treatment that is easy to implement,
minimally invasive, and precisely controllable, and evokes strong antitumor immunity. We …
minimally invasive, and precisely controllable, and evokes strong antitumor immunity. We …
[HTML][HTML] 肿瘤免疫微环境中cGAS-STING 信号通路的细胞间信号传递
王梦秋， 徐平龙， 吴芑柔 - Journal of Zhejiang University (Medical …, 2024 - ncbi.nlm.nih.gov
环鸟苷酸-腺苷酸合成酶（ cGAS）-干扰素基因刺激因子（ STING） 信号通路是肿瘤免疫治疗中备
受关注的靶点。 模式识别受体cGAS 识别胞质双链DNA（ dsDNA）， 生成第二信使2 3-环鸟苷酸 …
受关注的靶点。 模式识别受体cGAS 识别胞质双链DNA（ dsDNA）， 生成第二信使2 3-环鸟苷酸 …
外泌体MicroRNA 在抗病毒免疫中的功能分析
窦金萍， 高维崧， 韦双， 高新桃， 李轶女 - 生物技术通报, 2024 - biotech.aiijournal.com
外泌体是一种细胞外囊泡, 内含有多种蛋白质和细胞调节因子, 参与细胞间的信息传递并调控
细胞的生长和生理过程. 由于外泌体的功能差异性与分泌其细胞的类型和状态密切相关 …
细胞的生长和生理过程. 由于外泌体的功能差异性与分泌其细胞的类型和状态密切相关 …
Functional Analysis of Exosomal MicroRNA in Antiviral Immunity
J DOU, W GAO, S WEI, X GAO, Y LI - Biotechnology Bulletin, 2024 - biotech.aiijournal.com
Exosomes are extracellular vesicles that contain various proteins and cellular regulatory
factors, which participate in intercellular information transfer and regulate cell growth and …
factors, which participate in intercellular information transfer and regulate cell growth and …