Mesenchymal stem cells (MSCs) are multipotent cells that differentiate into the
mesenchymal lineages of adipocytes, osteocytes and chondrocytes. MSCs can also …

The central nervous system (CNS) has long been recognized as a site of 'immune
privilege'because of the existence of the blood brain barrier (BBB) which presumably …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by multi-focal demyelination, axonal loss, and immune cell infiltration …

Background Kv1. 3 potassium channels regulate microglial functions and are overexpressed
in neuroinflammatory diseases. Kv1. 3 blockade may selectively inhibit pro-inflammatory …

Background Multiple sclerosis is an inflammatory demyelinating disease of the central
nervous system in which autoreactive myelin-specific T cells cause extensive tissue …

Models of multiple sclerosis: new insights into pathophysiol... : Current Opinion in
Neurology Models of multiple sclerosis: new insights into pathophysiology and repair …

We have presently evaluated the effects of the immunomodulatory drug rapamycin on the
course of protracted relapsing experimental allergic encephalomyelitis (PR-EAE) in Dark …

Multiple sclerosis (MS) is a complex inflammatory and demyelinating disease of the central
nervous system (CNS) frequently starts in young adulthood. Demyelination, inflammatory …

Abstract IL‐23 but not IL‐12 is essential for the development of autoimmune tissue
inflammation in mice. Conversely, IL‐12 and IL‐23 impact on the polarization of Th1 and …

The trafficking of cytotoxic CD8+ T lymphocytes across the lining of the cerebral vasculature
is key to the onset of the chronic neuro-inflammatory disorder multiple sclerosis. However …