Gene therapy for neurological, and in particular neurodegenerative, disease is now a reality.
A number of early phase clinical trials have been completed and several are currently in …

Background: Myelin-specific T cells are implicated in multiple sclerosis (MS) and drive
experimental autoimmune encephalomyelitis (EAE). EAE is commonly induced with short …

Abstract γδ T cells represent a small subpopulation of T cells expressing a restricted
repertoire of T‐cell receptors and, unlike αβ T cells, function more as cells of the innate …

Increasing evidence suggests a role of CD8 T cells in autoimmune demyelinating CNS
disease, which, however, is still controversially discussed. Mice, which express ovalbumin …

Objective This study evaluated the clinical and pathological effects of the
immunosuppressive agent mycophenolate mofetil (MMF) in rats with experimental …

Aging is the gradual deterioration of molecular, cellular, and organismal function that occurs
over a lifetime. Half of the global adult disease burden is driven by diseases with incidence …

O trabalho desenvolvido nesta tese foi efetuado no Instituto de Investigação e Inovação em
Saúde da Universidade do Porto-Instituto de Biologia Molecular e Celular. Este trabalho foi …

Tandem mass spectrometry was used to identify naturally processed peptides bound to
MHC I and MHC II molecules in central nervous system (CNS) of eight patients with multiple …

Цель исследования-установление характера изменений состава пейеровых бляшек и
периферических лимфоузлов при развитии экспериментального аллергического …

La barrière hémo-encéphalique (BHE) est formée des cellules endothéliales
microvasculaires cérébrales reliées entre elles par des jonctions serrées. Grâce à sa …