Hsp90 is a ubiquitous molecular chaperone involved in many cell signaling pathways, and
its interactions with specific chaperones and cochaperones determines which client proteins …

Abstract The conserved H/ACA RNPs consist of one H/ACA RNA and 4 core proteins:
dyskerin, NHP2, NOP10, and GAR1. Its assembly requires several assembly factors. A pre …

During ribosome synthesis, ribosomal RNA is modified through the formation of many
pseudouridines and methylations which contribute to ribosome function across all domains …

The AAA+ ATPases pontin and reptin function in a staggering array of cellular processes
including chromatin remodeling, transcriptional regulation, DNA damage repair, and …

In vitro, assembly of box C/D small nucleolar ribonucleoproteins (snoRNPs) involves the
sequential recruitment of core proteins to snoRNAs. In vivo, however, assembly factors are …

snoRNAs (small nucleolar RNAs) constitute one of the largest and best-studied classes of
non-coding RNAs that confer enzymatic specificity. With associated proteins, these …

Human dyskerin is an evolutively conserved protein that participates in diverse nuclear
complexes: the H/ACA snoRNPs, that control ribosome biogenesis, RNA pseudouridylation …

ABSTRACT Small Nucleolar RNAs (snoRNAs) are an abundant group of non-coding RNAs
with well-defined roles in ribosomal RNA processing, folding and chemical modification …

SHQ1 is essential for biogenesis of H/ACA ribonucleoproteins, a class of molecules
important for processing ribosomal RNAs, modifying spliceosomal small nuclear RNAs and …

The relevance of the dysregulation of snoRNAs in human cancer has been widely
investigated and has challenged the view that snoRNAs merely function as house-keeping …