Biallelic SHQ1 variant-related neurodevelopmental disorder is extremely rare. To date, only
six affected individuals, from four families, have been reported. Here, we report eight …

The PAQosome is a large complex composed of the HSP90/R2TP chaperone and a
prefoldin-like module. It promotes the biogenesis of cellular machineries but it is unclear …

Dyskerin and its homologs are ancient and conserved enzymes that catalyze the most
common post-transcriptional modification found in cells, pseudouridylation. The resulting …

Telomerase is a complex ribonucleoprotein scaffolded by the telomerase RNA (TR).
Telomere lengthening by telomerase is essential to maintain the proliferative potential of …

T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with
complicated heterogeneity. Although expression profiling reveals common elevated genes …

Biogenesis of eukaryotic box C/D small nucleolar ribonucleoprotein particles (C/D
snoRNPs) involves conserved trans-acting factors, which are proposed to facilitate the …

Small nucleolar RNAs (snoRNAs) are noncoding RNA molecules of highly variable size,
usually ranging from 60 to 150 nucleotides. They are classified into H/ACA box snoRNAs …

Modern drug discovery relies on combinatorial screening campaigns to find drug molecules
targeting specific disease-associated proteins. The success of such campaigns often relies …

Telomeres are nucleo-protein structures located at the end of chromosomes that protect
them from degradation. Telomeres length is maintained by the activity of the telomerase …

Abstract INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits
multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and …