Die akute myeloische Leukämie (AML) ist eine klonale Erkrankung der hämatopoetischen
Stammzelle, die durch eine Akquisition diverser genetischer Alterationen charakterisiert ist …

Die Zielsetzungen der vorliegenden Arbeit waren die Identifizierung der Kopiezahl-
Veränderungen beim Prostatakarzinom mit der hochauflösenden SNP-Array Technologie …

The creation of eukaryotic ribosomes is a complex process involving hundreds of assembly
factors, including the small nucleolar RNA snR30. Through interacting with the unprocessed …

Telomeres are nucleoprotein structures located at the end of chromosomes. Telomere
length and the enzyme responsible for their elongation, telomerase, are essential for …

[ES] Las ataxias hereditarias constituyen un grupo heterogéneo de trastornos del
movimiento caracterizados principalmente por una afectación progresiva en la estabilidad …

H/ACA guide RNAs are a class of noncoding RNA that direct the pseudouridylation of many
cellular RNA species. In most eukaryotes, H/ACA guide RNAs share a conserved hairpin …

The huge increase of endometrial cancer incidence, with an associated rise in related
mortality, has highlighted the need to find reliable markers to identify the high-risk …

The aim of this thesis is to understand how the function of the H/ACA ribonucleoprotein and
telomerase component dyskerin is impacted in premature aging disease, and how dyskerin …

Telomeres, the protective caps at the end of human chromosomes, are shortened during
cellular proliferation in normal aging. Telomere biology disorders (TBDs) refer to a spectrum …

Combining biochemical characterization of cellular pH and redox state, metabolic
phenotyping, time-course metabolomics, whole-genome transcriptomics, and quantitative …