Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

The heat shock protein 90 (Hsp90) family consists of four highly conserved isoforms: the
mitochondrial TRAP-1, the endoplasmic reticulum-localised Grp94, and the cytoplasmic …

Heat shock protein 90, also known as Hsp90, is an extensively preserved molecular
chaperone that performs a critical function in organizing various biological pathways and …

Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes
cancer cell malignancy. To provide a better understanding of the biological processes …

Background Two activation states of reactive astrocytes termed A1 and A2 subtypes emerge
at the lesion sites following spinal cord injury (SCI). A1 astrocytes are known to be …

Background Diabetic peripheral neuropathy (DPN) constitutes a debilitating complication
associated with diabetes. Although, the past decade has seen rapid developments in …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are now known as
parts of a disease spectrum with common pathological features and genetic causes …

Heat shock proteins (HSPs) are highly conserved stress proteins known as molecular
chaperones, which are considered to be cytoplasmic proteins with functions restricted to the …

Introduction Diabetic peripheral neuropathy (DPN) is a common complication of both type 1
(T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets …

Patients with advanced bladder cancer gradually become less sensitive to
chemotherapeutic agents, leading to tumor recurrence. Initiating the senescence program in …