Mitochondria are organelles present in almost all eukaryotic cells, where they represent the
main site of energy production. Mitochondria are involved in several important cell …

Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low
acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These …

Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused by
heart pacing and conduction dysfunction. Arrhythmia is the leading cause of death in …

The most common alterations affecting mitochondria, and associated with cardiac
pathological conditions, implicate a long list of defects. They include impairments of the …

Extracellular vesicles (EVs) are nanosized particles with attractive therapeutic potential for
cardiac repair. However, low retention and stability after systemic administration limit their …

Many cardiovascular diseases originate from growth retardation, inflammation, and
malnutrition during early postnatal development. The nature of this phenomenon is not …

Heart failure with preserved ejection fraction (HFpEF) displays normal or near-normal left
ventricular ejection fraction, diastolic dysfunction, cardiac hypertrophy, and poor exercise …

Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin
conformation and stability, and its misregulation could lead to several diseases including …

PHARMACOM-EPI is a novel framework to predict plasma concentrations of drugs at the
time of occurrence of clinical outcomes. In early 2021, the US Food and Drug Administration …

Mast cells are granulocytic immune sentinels present in vascularized tissues that drive
chronic inflammatory mechanisms characteristic of allergic pathologies. IgE‐mediated mast …