Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer

X Tian, T Gu, MH Lee, Z Dong - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Lung cancer causes the highest mortality compared to other cancers in the world according
to the latest WHO reports. Non-small cell lung cancer (NSCLC) contributes about 85% of …

[HTML][HTML] Recent advances in targeted therapy for pancreatic adenocarcinoma

YT Fang, WW Yang, YR Niu, YK Sun - World journal of …, 2023 - ncbi.nlm.nih.gov
Pancreatic adenocarcinoma (PDAC) is a fatal disease with a 5-year survival rate of 8% and
a median survival of 6 mo. In PDAC, several mutations in the genes are involved, with …

Non–small cell lung cancer

DS Ettinger, W Akerley, H Borghaei, AC Chang… - Journal of the National …, 2012 - jnccn.org
Most patients with non–small cell lung cancer (NSCLC) are diagnosed with advanced
cancer. These guidelines only include information about stage IV NSCLC. Patients with …

[HTML][HTML] EGFR first-and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients

N Karachaliou, M Fernandez-Bruno… - Translational Cancer …, 2019 - ncbi.nlm.nih.gov
Identification of epidermal growth factor receptor (EGFR) as a molecular target has radically
changed the treatment of metastatic non-small cell lung cancer (NSCLC) from standard …

Repurposing FDA-approved drugs against the toxicity of platinum-based anticancer drugs

AC Famurewa, AG Mukherjee, UR Wanjari, A Sukumar… - Life Sciences, 2022 - Elsevier
Platinum-based anticancer drugs (PADs), mainly cisplatin, carboplatin, and oxaliplatin, are
widely used efficacious long-standing anticancer agents for treating several cancer types …

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets

JM Drake, NA Graham, JK Lee… - Proceedings of the …, 2013 - National Acad Sciences
In prostate cancer, multiple metastases from the same patient share similar copy number,
mutational status, erythroblast transformation specific (ETS) rearrangements, and …

[HTML][HTML] Primary endpoints to assess the efficacy of novel therapeutic approaches in epidermal growth factor receptor-mutated, surgically resectable non-small cell …

CM Blakely, W Weder, L Bubendorf, J He, M Majem… - Lung Cancer, 2023 - Elsevier
While the discovery of oncogenic driver mutations has personalized the metastatic non-
small cell lung cancer (NSCLC) treatment landscape with effective targeted therapies …

[HTML][HTML] Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway

L Li, W Huang, K Li, K Zhang, C Lin, R Han, C Lu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Interstitial lung disease (ILD) is a serious side-effect of epidermal growth factor receptor
(EGFR)-tyrosine kinase inhibitor (TKI) treatment. Therefore, it is necessary to study …

Delivery of RNAi therapeutics to the airways—from bench to bedside

Y Qiu, JKW Lam, SWS Leung, W Liang - Molecules, 2016 - mdpi.com
RNA interference (RNAi) is a potent and specific post-transcriptional gene silencing process.
Since its discovery, tremendous efforts have been made to translate RNAi technology into …

Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitors

APS Silva, PV Coelho, M Anazetti… - Human vaccines & …, 2017 - Taylor & Francis
The usual treatments for patients with non-small-cell lung cancer (NSCLC), such as
advanced lung adenocarcinoma, are unspecific and aggressive, and include lung resection …