Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer
Lung cancer causes the highest mortality compared to other cancers in the world according
to the latest WHO reports. Non-small cell lung cancer (NSCLC) contributes about 85% of …
to the latest WHO reports. Non-small cell lung cancer (NSCLC) contributes about 85% of …
[HTML][HTML] Recent advances in targeted therapy for pancreatic adenocarcinoma
YT Fang, WW Yang, YR Niu, YK Sun - World journal of …, 2023 - ncbi.nlm.nih.gov
Pancreatic adenocarcinoma (PDAC) is a fatal disease with a 5-year survival rate of 8% and
a median survival of 6 mo. In PDAC, several mutations in the genes are involved, with …
a median survival of 6 mo. In PDAC, several mutations in the genes are involved, with …
Non–small cell lung cancer
Most patients with non–small cell lung cancer (NSCLC) are diagnosed with advanced
cancer. These guidelines only include information about stage IV NSCLC. Patients with …
cancer. These guidelines only include information about stage IV NSCLC. Patients with …
[HTML][HTML] EGFR first-and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
N Karachaliou, M Fernandez-Bruno… - Translational Cancer …, 2019 - ncbi.nlm.nih.gov
Identification of epidermal growth factor receptor (EGFR) as a molecular target has radically
changed the treatment of metastatic non-small cell lung cancer (NSCLC) from standard …
changed the treatment of metastatic non-small cell lung cancer (NSCLC) from standard …
Repurposing FDA-approved drugs against the toxicity of platinum-based anticancer drugs
AC Famurewa, AG Mukherjee, UR Wanjari, A Sukumar… - Life Sciences, 2022 - Elsevier
Platinum-based anticancer drugs (PADs), mainly cisplatin, carboplatin, and oxaliplatin, are
widely used efficacious long-standing anticancer agents for treating several cancer types …
widely used efficacious long-standing anticancer agents for treating several cancer types …
Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets
In prostate cancer, multiple metastases from the same patient share similar copy number,
mutational status, erythroblast transformation specific (ETS) rearrangements, and …
mutational status, erythroblast transformation specific (ETS) rearrangements, and …
[HTML][HTML] Primary endpoints to assess the efficacy of novel therapeutic approaches in epidermal growth factor receptor-mutated, surgically resectable non-small cell …
CM Blakely, W Weder, L Bubendorf, J He, M Majem… - Lung Cancer, 2023 - Elsevier
While the discovery of oncogenic driver mutations has personalized the metastatic non-
small cell lung cancer (NSCLC) treatment landscape with effective targeted therapies …
small cell lung cancer (NSCLC) treatment landscape with effective targeted therapies …
[HTML][HTML] Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway
L Li, W Huang, K Li, K Zhang, C Lin, R Han, C Lu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Interstitial lung disease (ILD) is a serious side-effect of epidermal growth factor receptor
(EGFR)-tyrosine kinase inhibitor (TKI) treatment. Therefore, it is necessary to study …
(EGFR)-tyrosine kinase inhibitor (TKI) treatment. Therefore, it is necessary to study …
Delivery of RNAi therapeutics to the airways—from bench to bedside
RNA interference (RNAi) is a potent and specific post-transcriptional gene silencing process.
Since its discovery, tremendous efforts have been made to translate RNAi technology into …
Since its discovery, tremendous efforts have been made to translate RNAi technology into …
Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitors
APS Silva, PV Coelho, M Anazetti… - Human vaccines & …, 2017 - Taylor & Francis
The usual treatments for patients with non-small-cell lung cancer (NSCLC), such as
advanced lung adenocarcinoma, are unspecific and aggressive, and include lung resection …
advanced lung adenocarcinoma, are unspecific and aggressive, and include lung resection …