Seizures affect the lives of 10% of the global population and result in epilepsy in 1 to 2% of
people around the world. Current knowledge about etiology, diagnosis, and treatments for …

This review discusses the updated classifications of seizures and the epilepsies, which were
recently published by the International League Against Epilepsy (ILAE). While it is always a …

Epilepsy affects 65 million people worldwide and entails a major burden in seizure-related
disability, mortality, comorbidities, stigma, and costs. In the past decade, important advances …

Sequencing-based studies have identified novel risk genes associated with severe
epilepsies and revealed an excess of rare deleterious variation in less-severe forms of …

Understanding the aetiology of epilepsy is essential both for clinical management of patients
and for conducting neurobiological research that will direct future therapies. The aetiology of …

Zebrafish are increasingly being utilized as a model system to investigate the function of the
growing list of risk genes associated with neurodevelopmental disorders. This is due in large …

Epilepsy is a group of disorders characterized by recurrent seizures, and is one of the most
common neurological conditions. The genetic basis of epilepsy is clear from epidemiological …

Targeted resequencing gene panels are used in the diagnostic setting to identify gene
defects in epilepsy. We performed targeted resequencing using a 30‐genes panel and a 95 …

US9834791B2 - CRISPR-related methods and compositions with governing gRNAS -
Google Patents US9834791B2 - CRISPR-related methods and compositions with …

Objective We evaluated the yield of systematic analysis and/or reanalysis of whole exome
sequencing (WES) data from a cohort of well‐phenotyped pediatric patients with epilepsy …