Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Glial cells: role of the immune response in ischemic stroke

S Xu, J Lu, A Shao, JH Zhang, J Zhang - Frontiers in immunology, 2020 - frontiersin.org
Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

Macrophage‐disguised manganese dioxide nanoparticles for neuroprotection by reducing oxidative stress and modulating inflammatory microenvironment in acute …

C Li, Z Zhao, Y Luo, T Ning, P Liu, Q Chen… - Advanced …, 2021 - Wiley Online Library
Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic
stroke. However, the current clinical treatments are remained on single pathological …

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐κB Suppression and NLRP3 …

Y Ran, W Su, F Gao, Z Ding, S Yang… - Oxidative medicine …, 2021 - Wiley Online Library
NLRP3 inflammasome‐mediated pyroptosis is a proinflammatory programmed cell death
pathway, which plays a vital role in functional outcomes after stroke. We previously …

[HTML][HTML] M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124

Y Song, Z Li, T He, M Qu, L Jiang, W Li, X Shi, J Pan… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Microglia play a critical role in modulating cell death and neurobehavioral
recovery in response to brain injury either by direct cell-cell interaction or indirect secretion …

The predictive role of systemic inflammation response index (SIRI) in the prognosis of stroke patients

Y Zhang, Z Xing, K Zhou, S Jiang - Clinical interventions in aging, 2021 - Taylor & Francis
Purpose Stroke is a disease associated with high mortality. Many inflammatory indicators
such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte …

Dual functions of microglia in ischemic stroke

C Qin, LQ Zhou, XT Ma, ZW Hu, S Yang, M Chen… - Neuroscience …, 2019 - Springer
Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia
are the principal immune cells of the brain, and the first to respond to the pathophysiological …

Microglia and inflammatory responses in diabetic retinopathy

UM Kinuthia, A Wolf, T Langmann - Frontiers in immunology, 2020 - frontiersin.org
Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature
of the retina. The development of this disease is associated with the action of inflammatory …

[HTML][HTML] Ischemia/reperfusion

T Kalogeris, CP Baines, M Krenz… - Comprehensive …, 2016 - ncbi.nlm.nih.gov
Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Neuroinflammation in vascular cognitive impairment and dementia: current evidence, advances, and prospects

Z Tian, X Ji, J Liu - International Journal of Molecular Sciences, 2022 - mdpi.com
Vascular cognitive impairment and dementia (VCID) is a major heterogeneous brain
disease caused by multiple factors, and it is the second most common type of dementia in …