Purpose This study assessed the prognostic impact of postinduction NPM1-mutated (NPM1
m) minimal residual disease (MRD) in young adult patients (age, 18 to 60 years) with acute …

Background The full complement of DNA mutations that are responsible for the
pathogenesis of acute myeloid leukemia (AML) is not yet known. Methods We used …

The initiating mutations that contribute to cancer development are sometimes present in
premalignant cells. Whether therapies targeting these mutations can eradicate premalignant …

THE manufacture of predefined specific antibodies by means of permanent tissue culture
cell lines is of general interest. There are at present a considerable number of permanent …

Current risk algorithms are primarily based on pre-treatment factors and imperfectly predict
outcome in acute myeloid leukemia (AML). We introduce and validate a post-treatment …

Purpose To analyze the frequency and associations with prognostic markers and outcome of
mutations in IDH genes encoding isocitrate dehydrogenases in adult de novo …

Background Mutations occur in several genes in cytogenetically normal acute myeloid
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 …

We hypothesized that DNA methylation distributes into specific patterns in cancer cells,
which reflect critical biological differences. We therefore examined the methylation profiles of …

Purpose Antibody-directed chemotherapy for acute myeloid leukemia (AML) may permit
more treatment to be administered without escalating toxicity. Gemtuzumab ozogamicin …

Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML)
have revealed a striking heterogeneity with regard to the presence of acquired gene …