Molecular MRD status and outcome after transplantation in NPM1-mutated AML
Relapse remains the most common cause of treatment failure for patients with acute myeloid
leukemia (AML) who undergo allogeneic stem cell transplantation (alloSCT), and carries a …
leukemia (AML) who undergo allogeneic stem cell transplantation (alloSCT), and carries a …
Automated blast cell detection for Acute Lymphoblastic Leukemia diagnosis
R Khandekar, P Shastry, S Jaishankar, O Faust… - … Signal Processing and …, 2021 - Elsevier
Abstract Acute Lymphoblastic Leukemia (ALL) is a cancer of the blood cells which is
characterized by a large number of immature lymphocytes, known as blast cells …
characterized by a large number of immature lymphocytes, known as blast cells …
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about
13,000 adults in the United States each year. The treatment of this disease has changed …
13,000 adults in the United States each year. The treatment of this disease has changed …
The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach
JJ Cornelissen, A Gratwohl, RF Schlenk… - Nature reviews Clinical …, 2012 - nature.com
Allogeneic haematopoietic stem-cell transplantation (HSCT) is frequently applied as part of
the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent …
the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent …
Acute myeloid leukaemia
E Estey, H Döhner - The Lancet, 2006 - thelancet.com
Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haemopoietic
progenitor cells and the most common malignant myeloid disorder in adults. The median …
progenitor cells and the most common malignant myeloid disorder in adults. The median …
The role of HOX genes in normal hematopoiesis and acute leukemia
RA Alharbi, R Pettengell, HS Pandha, R Morgan - Leukemia, 2013 - nature.com
The homeobox (HOX) genes are a highly conserved family of homeodomain-containing
transcription factors that specify cell identity in early development and, subsequently, in a …
transcription factors that specify cell identity in early development and, subsequently, in a …
MRD in AML: the role of new techniques
MT Voso, T Ottone, S Lavorgna, A Venditti… - Frontiers in …, 2019 - frontiersin.org
In the context of precision medicine, assessment of minimal residual disease (MRD) has
been used in acute myeloid leukemia (AML) to direct individual treatment programs …
been used in acute myeloid leukemia (AML) to direct individual treatment programs …
The regulation of INK4/ARF in cancer and aging
WY Kim, NE Sharpless - Cell, 2006 - cell.com
Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent
cytogenetic events in human cancer. The products of the locus—p15 INK4b, p16 INK4a, and …
cytogenetic events in human cancer. The products of the locus—p15 INK4b, p16 INK4a, and …
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly
expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found …
expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found …
Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia
DI van der Lee, RM Reijmers… - The Journal of …, 2019 - Am Soc Clin Investig
The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the
nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive target for …
nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive target for …