In mammalian genomes, the methylation of cytosine residues within CpG dinucleotides is
crucial to normal development and cell differentiation. However, methylation of cytosines in …

This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …

The process of oncogene-induced senescence (OIS) and the conversion between OIS and
malignant transformation during carcinogenesis is poorly understood. Here, we show that …

Background: Bim is a Bcl-2 homology 3 (BH3)-only proteins, a group of pro-apoptotic
proteins involved in physiological and pathological conditions. Both the overexpression and …

Within nine dentin dysplasia (DD)(type II) and dentinogenesis imperfecta (type II and III)
patient/families, seven have 1 of 4 net–1 deletions within the∼ 2‐kb coding repeat domain …

Lung cancer, the leading cause of mortality in both men and women in the United States, is
largely diagnosed at its advanced stages that there are no effective therapeutic alternatives …

DNA methylation is one of epigenetic mechanisms regulating gene expression. The
methylation pattern is determined during embryogenesis and passed over to differentiating …

The role of gene body methylation, which represents a major part of methylation in DNA,
remains mostly unknown. Evidence based on the CpG distribution associates its presence …

The methylation of cytosine residues that precede adenine/thymine or other cytosine
nucleotides instead of guanine in DNA is known as non-CpG methylation. It is a pronounced …

The dynamic changes and structural patterns of DNA methylation of genes without CpG
islands are poorly characterized. The relevance of CpG to the non-CpG methylation …