[HTML][HTML] Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

[HTML][HTML] Calcium phosphate nanoparticles for therapeutic applications in bone regeneration

TJ Levingstone, S Herbaj, NJ Dunne - Nanomaterials, 2019 - mdpi.com
Bone injuries and diseases constitute a burden both socially and economically, as the
consequences of a lack of effective treatments affect both the patients' quality of life and the …

Materials science and design principles of growth factor delivery systems in tissue engineering and regenerative medicine

R Subbiah, RE Guldberg - Advanced healthcare materials, 2019 - Wiley Online Library
Growth factors (GFs) are signaling molecules that direct cell development by providing
biochemical cues for stem cell proliferation, migration, and differentiation. GFs play a key …

[HTML][HTML] The role of micro RNA and long-non-coding RNA in osteoporosis

NY Ko, LR Chen, KH Chen - International Journal of Molecular Sciences, 2020 - mdpi.com
Osteoporosis is a major concern worldwide and can be attributed to an imbalance between
osteoblastic bone formation and osteoclastic bone resorption due to the natural aging …

[HTML][HTML] The role of miR-21 in osteoblasts–osteoclasts coupling in vitro

A Smieszek, K Marcinkowska, A Pielok, M Sikora… - Cells, 2020 - mdpi.com
MiR-21 is being gradually more and more recognized as a molecule regulating bone tissue
homeostasis. However, its function is not fully understood due to the dual role of miR-21 on …

Promoting osteogenic differentiation of human adipose‐derived stem cells by altering the expression of exosomal miRNA

S Yang, S Guo, S Tong, X Sun - Stem Cells International, 2019 - Wiley Online Library
Human adipose‐derived stem cells (ADSCs) can release exosomes; however, their specific
functions remain elusive. In this study, we verified that exosomes derived from …

[HTML][HTML] Calcium phosphate nanoparticles-based systems for RNAi delivery: Applications in bone tissue regeneration

TJ Levingstone, S Herbaj, J Redmond, HO McCarthy… - Nanomaterials, 2020 - mdpi.com
Bone-related injury and disease constitute a significant global burden both socially and
economically. Current treatments have many limitations and thus the development of new …

[HTML][HTML] MiRNAs expression modulates osteogenesis in response to exercise and nutrition

P Proia, C Rossi, A Alioto, A Amato, C Polizzotto… - Genes, 2023 - mdpi.com
In recent years, many articles have been published describing the impact of physical activity
and diet on bone health. This review has aimed to figure out the possible epigenetic …

[HTML][HTML] Roles of MicroRNAs in osteogenesis or adipogenesis differentiation of bone marrow stromal progenitor cells

YL Zhang, L Liu, Y Peymanfar, P Anderson… - International Journal of …, 2021 - mdpi.com
Bone marrow stromal cells (BMSCs) are multipotent cells which can differentiate into
chondrocytes, osteoblasts, and fat cells. Under pathological stress, reduced bone formation …