Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms

X Huang, B Hussain, J Chang - CNS neuroscience & …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

[HTML][HTML] Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety

F Fan, L Yang, R Li, X Zou, N Li, X Meng… - Biomedicine & …, 2020 - Elsevier
Salidroside (Sal) is a bioactive extract principally from traditional herbal medicine such as
Rhodiola rosea L., which has been commonly used for hundreds of years in Asia countries …

The central role of peripheral inflammation in ischemic stroke

M Monsour, CV Borlongan - Journal of Cerebral Blood Flow …, 2023 - journals.sagepub.com
Stroke pathology and its treatments conventionally focus on the brain. Probing inflammation,
a critical secondary cell death mechanism in stroke, has been largely relegated to the brain …

Macrophage and monocyte subsets in response to ischemic stroke

N Blank‐Stein, E Mass - European Journal of Immunology, 2023 - Wiley Online Library
Ischemic stroke is a leading cause of disability and mortality. Despite extensive efforts in
stroke research, the only pharmacological treatment currently available is arterial …

Macrophage membrane modified baicalin liposomes improve brain targeting for alleviating cerebral ischemia reperfusion injury

Y Long, Y Xiang, S Liu, Y Zhang, J Wan, Z Ci… - … , Biology and Medicine, 2022 - Elsevier
Baicalin (BA) has a good intervention effect on encephalopathy. In this study, macrophage
membrane was modified on the surface of baicalin liposomes (BA-LP) by extrusion method …

Novel multifunctional bionanoparticles modified with sialic acid for stroke treatment

Y Su, C Guo, Q Chen, H Guo, J Wang… - International journal of …, 2022 - Elsevier
Oxidative stress and inflammation are two key pathophysiological mechanisms that lead to
neuronal apoptosis and brain damage following ischemia/reperfusion (I/R) injury. Because …

3D Coculture between Cancer Cells and Macrophages: From Conception to Experimentation

R Quoniou, E Moreau, F Cachin… - ACS Biomaterials …, 2023 - ACS Publications
A tumor is a complex cluster with many types of cells in the microenvironment that help it
grow. Macrophages, immune cells whose main role is to maintain body homeostasis …

Metabolic determinants of leukocyte pathogenicity in neurological diseases

MC Runtsch, G Ferrara, S Angiari - Journal of neurochemistry, 2021 - Wiley Online Library
Neuroinflammatory and neurodegenerative diseases are characterized by the recruitment of
circulating blood‐borne innate and adaptive immune cells into the central nervous system …

Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review

M Monsour, J Gordon, G Lockard… - Cell …, 2023 - journals.sagepub.com
The immense neuroinflammation induced by multiple sclerosis (MS) promotes a favorable
environment for ischemic stroke (IS) development, making IS a deadly complication of MS …

Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling

C Wu, L Wu, Y Ha, Y Zou, K Shi, J Xing, Y Zhao, J Guo… - 2023 - researchsquare.com
Purpose: Epigenetic modifications have important impacts on the biological functions of
cells. This study explored the effects of SET domain-containing protein (SETD) 4, a histone …