[HTML][HTML] Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
[HTML][HTML] Acute kidney injury following cardiac surgery: current understanding and future directions
Acute kidney injury (AKI) complicates recovery from cardiac surgery in up to 30% of patients,
injures and impairs the function of the brain, lungs, and gut, and places patients at a 5-fold …
injures and impairs the function of the brain, lungs, and gut, and places patients at a 5-fold …
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
The generation of organoids is one of the biggest scientific advances in regenerative
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …
Generation of kidney organoids from human pluripotent stem cells
The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …
[HTML][HTML] Molecular mechanisms of kidney injury and repair
S Rayego-Mateos, L Marquez-Expósito… - International journal of …, 2022 - mdpi.com
Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …
emphasizing the need to better understand the molecular mechanisms of damage and …
[HTML][HTML] Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids
JM Vanslambrouck, SB Wilson, KS Tan… - Nature …, 2022 - nature.com
While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional …
disease, the proximal nephron remains immature with limited evidence for key functional …
Biomaterials‐based approaches to tumor spheroid and organoid modeling
Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …
development of physiologically relevant tumor models for cancer research and drug …
[HTML][HTML] Exosomes from human-induced pluripotent stem cell–derived mesenchymal stromal cells (hiPSC-MSCs) protect liver against hepatic ischemia/reperfusion …
Y Du, D Li, C Han, H Wu, L Xu, M Zhang… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: This study aimed to evaluate the effects of exosomes produced by human-
induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs-Exo) on …
induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs-Exo) on …
[HTML][HTML] A modular differentiation system maps multiple human kidney lineages from pluripotent stem cells
H Tsujimoto, T Kasahara, S Sueta, T Araoka… - Cell reports, 2020 - cell.com
Recent studies using human pluripotent stem cells (hPSCs) have developed protocols to
induce kidney-lineage cells and reconstruct kidney organoids. However, the separate …
induce kidney-lineage cells and reconstruct kidney organoids. However, the separate …
[HTML][HTML] 3D culture supports long-term expansion of mouse and human nephrogenic progenitors
Transit-amplifying nephron progenitor cells (NPCs) generate all of the nephrons of the
mammalian kidney during development. Their limited numbers, poor in vitro expansion, and …
mammalian kidney during development. Their limited numbers, poor in vitro expansion, and …