[HTML][HTML] Biomedical polymers: synthesis, properties, and applications

WH Chen, QW Chen, Q Chen, C Cui, S Duan… - Science China …, 2022 - Springer
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

M Zoulikha, Q Xiao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …

Microenvironment‐activated Nanozyme‐armed bacteriophages efficiently combat bacterial infection

L Jin, F Cao, Y Gao, C Zhang, Z Qian… - Advanced …, 2023 - Wiley Online Library
Bacterial infection is one of the greatest challenges to public health, requiring new
therapeutic methods. Herein, an innovative nanozyme‐armed phage (phage@ palladium …

Chemically modified platforms for better RNA therapeutics

Y Shi, X Zhen, Y Zhang, Y Li, S Koo, Q Saiding… - Chemical …, 2024 - ACS Publications
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

A multifunctional nanoparticle mitigating cytokine storm by scavenging multiple inflammatory mediators of sepsis

Z Li, Y Feng, S Zhang, T Li, H Li, D Wang, K Hao… - ACS …, 2023 - ACS Publications
Sepsis is a disease caused by infection, which is characterized by a dysregulated immune
response in the host and affects more than 30 million people worldwide each year …

Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy

Z Jin, Q Gao, K Wu, J Ouyang, W Guo… - Advanced Drug Delivery …, 2023 - Elsevier
The lack of effective treatments for pulmonary diseases presents a significant global health
burden, primarily due to the challenges posed by the pulmonary barrier that hinders drug …

An inhalable hybrid biomimetic nanoplatform for sequential drug release and remodeling lung immune homeostasis in acute lung injury treatment

C Liu, L Xi, Y Liu, JCW Mak, S Mao, Z Wang, Y Zheng - ACS nano, 2023 - ACS Publications
Interactions of lung macrophages and recruited neutrophils with the lung microenvironment
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …

Self-amplifying assembly of peptides in macrophages for enhanced inflammatory treatment

Y Song, M Li, N Song, X Liu, G Wu… - Journal of the …, 2022 - ACS Publications
Enzyme-regulated in situ self-assembly of peptides represents one versatile strategy in the
creation of theranostic agents, which, however, is limited by the strong dependence on …

Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome

C Zhuang, M Kang, M Lee - Journal of Controlled Release, 2023 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a devastating
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …

[HTML][HTML] Phosphorus dendron nanomicelles as a platform for combination anti-inflammatory and antioxidative therapy of acute lung injury

J Li, L Chen, C Li, Y Fan, M Zhan, H Sun, S Mignani… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Development of novel nanomedicines to inhibit pro-inflammatory cytokine
expression and reactive oxygen species (ROS) generation for anti-inflammatory therapy of …