The adult brain is a plastic place. To ensure that the mature nervous system's control of
behaviour is flexible in the face of a varying environment, morphological and physiological …

The discovery that the adult mammalian brain creates new neurons from pools of stemlike
cells was a breakthrough in neuroscience. Interestingly, this particular new form of structural …

The cells of organisms as diverse as bacteria and humans can enter stable, nonproliferating
quiescent states. Quiescent cells of eukaryotic and prokaryotic microorganisms can survive …

The importance of the p53 protein in the cellular response to DNA damage is well known,
but its function during steady-state hematopoiesis has not been established. We have …

While a massive and progressive neuronal loss in specific areas such as the hippocampus
and cortex unequivocally underlies cognitive deterioration and memory loss in Alzheimer's …

Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

Prader-Willi syndrome (PWS) is a complex human genetic disease that arises from lack of
expression of paternally inherited imprinted genes on chromosome 15q11-q13 …

▪ Abstract Tumors of the central nervous system (CNS) can be devastating because they
often affect children, are difficult to treat, and frequently cause mental impairment or death …

Apoptosis of neurons is indispensable to the normal development of the nervous system and
contributes to neuronal loss in neurologic injury and disease. Life and death decisions are …

Bone morphogenetic proteins (BMPs) have diverse and sometimes paradoxical effects
during embryonic development. To determine the mechanisms underlying BMP actions, we …