Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that leads to
progressive disability and motor impairment. Existing therapies provide modest …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and
lower motor neurons. As a consequence, ALS patients display a locomotor disorder related …

Optineurin is a multifunctional polyubiquitin-binding protein implicated in inflammatory
signalling. Optineurin mutations are associated with amyotrophic lateral sclerosis (ALS) and …

Traumatic brain injury (TBI) is one of the most common pathological conditions impacting the
central nervous system (CNS). A neurological deficit associated with TBI results from a …

Zebrafish are widely considered an excellent vertebrate model for studying the
pathogenesis of human diseases because of their transparency of embryonic development …

In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical
and spinal cord motor neurons triggers the activation of the integrated stress response (ISR) …

Background and Purpose The integrated stress response (ISR) regulates translation in
response to diverse stresses. ISR activation has been documented in amyotrophic lateral …

Amyotrophic Lateral Sclerosis is a neurodegenerative disease caused by progressive loss
of motor neurons, which severely compromises skeletal muscle function. Evidence shows …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which the death of
motor neurons leads to loss of muscle function. Additionally, cognitive and circadian …