Potential roles of gut microbes in biotransformation of natural products: An overview

Y Zhao, X Zhong, J Yan, C Sun, X Zhao… - Frontiers in …, 2022 - frontiersin.org
Natural products have been extensively applied in clinical practice, characterized by multi-
component and multi-target, many pharmacodynamic substances, complex action …

Chemical Analysis of the Herbal Medicine Salviae miltiorrhizae Radix et Rhizoma (Danshen)

H Pang, L Wu, Y Tang, G Zhou, C Qu, J Duan - Molecules, 2016 - mdpi.com
Radix Salviae miltiorrhizae et Rhizoma, known as Danshen in China, is one of the most
popular traditional Chinese medicines. Recently, there has been increasing scientific …

Danshen (Salvia miltiorrhiza Bunge): a prospective healing sage for cardiovascular diseases

W Chen, G Chen - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Danshen (Salvia miltiorrhiza Bunge) is a valued herbal plant in the Traditional Chinese
Medicine. The dried root of this plant (Radix Salvia miltiorrhiza), either alone or in …

Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: an integrated strategy based on UPLC-QTOF/MS combined with multivariate statistical …

N Mi, T Cheng, H Li, P Yang, X Mu, X Wang… - … of Pharmaceutical and …, 2019 - Elsevier
Metabolites derived from traditional Chinese medicine (TCM) are becoming active
substances of pharmacologically as well as promising sources for discovering new drugs …

Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3, 4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae= Danshen …

C Guo, Y Yin, J Duan, Y Zhu, J Yan, G Wei, Y Guan… - Phytomedicine, 2015 - Elsevier
Sodium danshensu (SDSS), the sodium salt of danshensu (DSS), has the same
pharmacological effects as DSS. In the present study, we aimed to investigate the …

Danshen (Salvia miltiorrhiza) water extract inhibits paracetamol-induced toxicity in primary rat hepatocytes via reducing CYP2E1 activity and oxidative stress

X Zhou, CM Cheung, J Yang, PMY Or… - Journal of Pharmacy …, 2015 - academic.oup.com
Objectives This study aimed to investigate the protective effects of Danshen (S alvia
miltiorrhiza) water extract (DSE) and its major phenolic acid components against CYP2E1 …

Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats

X Meng, J Jiang, H Pan, S Wu, S Wang… - Frontiers in …, 2019 - frontiersin.org
In this study, the absorption, distribution, metabolism and excretion (ADME) of sodium
danshensu (Sodium DL-β-(3, 4-dihydroxyphenyl) lactate), one of the main water-soluble …

Characterization of metabolites in rats after intravenous administration of salvianolic acid for injection by ultra‐performance liquid chromatography coupled with …

J Miao, W Sun, J Huang, X Liu, S Li… - Biomedical …, 2016 - Wiley Online Library
It is an essential requirement to clarify the metabolites of traditional Chinese medicine (TCM)
injections, which contain numerous ingredients, to assess their safe and effective use in …

Metabolite identification of salvianolic acid A in rat using post collision-induced dissociation energy-resolved mass spectrometry

H Li, K Zhang, W Chen, Y Zhou, J Li, Y Zhao, Y Song - Chinese Medicine, 2024 - Springer
Background As one of the most famous natural products, salvianolic acid A (SAA) is
undergoing clinical trials for the treatments of angina pectoris and coronary heart disorders …

HPLC/Q‐TOF‐MS‐Based Identification of Absorbed Constituents and Their Metabolites in Rat Serum and Urine after Oral Administration of Cistanche deserticola …

WL Li, XM Sun, H Song, JX Ding, J Bai… - Journal of Food …, 2015 - Wiley Online Library
As a famous health food in China, Cistanche deserticola (C. deserticola) suggested an
estrogenic activity according to our previous study. However, no one clarifies its active …