Tumor targeting strategies of smart fluorescent nanoparticles and their applications in cancer diagnosis and treatment
Advantages such as strong signal strength, resistance to photobleaching, tunable
fluorescence emissions, high sensitivity, and biocompatibility are the driving forces for the …
fluorescence emissions, high sensitivity, and biocompatibility are the driving forces for the …
Nucleic‐acid structures as intracellular probes for live cells
The chemical composition of cells at the molecular level determines their growth,
differentiation, structure, and function. Probing this composition is powerful because it …
differentiation, structure, and function. Probing this composition is powerful because it …
Molecular identification of tumor-derived extracellular vesicles using thermophoresis-mediated DNA computation
Molecular profiling of tumor-derived extracellular vesicles (tEVs) holds great promise for non-
invasive cancer diagnosis. However, sensitive and accurate identification of tEVs is …
invasive cancer diagnosis. However, sensitive and accurate identification of tEVs is …
Thermophoretic detection of exosomal microRNAs by nanoflares
J Zhao, C Liu, Y Li, Y Ma, J Deng, L Li… - Journal of the American …, 2020 - ACS Publications
Exosomal microRNAs (miRNAs) are reliable and noninvasive biomarkers for the early
diagnosis of cancer. Yet, accurate and feasible detection of exosomal miRNAs is often …
diagnosis of cancer. Yet, accurate and feasible detection of exosomal miRNAs is often …
Activating a DNA nanomachine via computation across cancer cell membranes for precise therapy of solid tumors
Y Zhang, W Chen, Y Fang, X Zhang… - Journal of the American …, 2021 - ACS Publications
Taking advantage of cancer cells' endogenous characters, the responsive activation of DNA
nanomachines has achieved great success in tumor therapy. Combining with extra stimuli …
nanomachines has achieved great success in tumor therapy. Combining with extra stimuli …
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
R Liu, L He, Y Hu, Z Luo, J Zhang - Chemical Science, 2020 - pubs.rsc.org
Rapid and accurate diagnosis of COVID-19 plays an essential role in the current epidemic
prevention and control. Despite the promise of nucleic acid and antibody tests, there is still a …
prevention and control. Despite the promise of nucleic acid and antibody tests, there is still a …
Equipping natural killer cells with specific targeting and checkpoint blocking aptamers for enhanced adoptive immunotherapy in solid tumors
Herein, we propose an aptamer‐equipping strategy to generate specific, universal and
permeable (SUPER) NK cells for enhanced immunotherapy in solid tumors. NK cells were …
permeable (SUPER) NK cells for enhanced immunotherapy in solid tumors. NK cells were …
Three-dimensional DNA nanostructures to improve the hyperbranched hybridization chain reaction
J Wang, DX Wang, JY Ma, YX Wang, DM Kong - Chemical Science, 2019 - pubs.rsc.org
Nonenzymatic nucleic acid amplification techniques (eg the hybridization chain reaction,
HCR) have shown promising potential for amplified detection of biomarkers. However, the …
HCR) have shown promising potential for amplified detection of biomarkers. However, the …
Integrating DNA nanotechnology with aptamers for biological and biomedical applications
Z Huang, L Qiu, T Zhang, W Tan - Matter, 2021 - cell.com
In addition to critical biological roles, DNA is also considered an excellent engineering
material with unique characteristics of high programmability and addressability. Recent …
material with unique characteristics of high programmability and addressability. Recent …
Simultaneous visualization of dual intercellular signal transductions via SERS imaging of membrane proteins dimerization on single cells
C Dong, X Fang, J Xiong, J Zhang, H Gan, C Song… - ACS …, 2022 - ACS Publications
The visualization of protein dimerization on live cells is an urgent need and of vital
importance for facile monitoring the signal transduction during intercellular communication …
importance for facile monitoring the signal transduction during intercellular communication …