Tumor targeting strategies of smart fluorescent nanoparticles and their applications in cancer diagnosis and treatment

J He, C Li, L Ding, Y Huang, X Yin, J Zhang… - Advanced …, 2019 - Wiley Online Library
Advantages such as strong signal strength, resistance to photobleaching, tunable
fluorescence emissions, high sensitivity, and biocompatibility are the driving forces for the …

Nucleic‐acid structures as intracellular probes for live cells

D Samanta, SB Ebrahimi, CA Mirkin - Advanced Materials, 2020 - Wiley Online Library
The chemical composition of cells at the molecular level determines their growth,
differentiation, structure, and function. Probing this composition is powerful because it …

Molecular identification of tumor-derived extracellular vesicles using thermophoresis-mediated DNA computation

Y Li, J Deng, Z Han, C Liu, F Tian, R Xu… - Journal of the …, 2021 - ACS Publications
Molecular profiling of tumor-derived extracellular vesicles (tEVs) holds great promise for non-
invasive cancer diagnosis. However, sensitive and accurate identification of tEVs is …

Thermophoretic detection of exosomal microRNAs by nanoflares

J Zhao, C Liu, Y Li, Y Ma, J Deng, L Li… - Journal of the American …, 2020 - ACS Publications
Exosomal microRNAs (miRNAs) are reliable and noninvasive biomarkers for the early
diagnosis of cancer. Yet, accurate and feasible detection of exosomal miRNAs is often …

Activating a DNA nanomachine via computation across cancer cell membranes for precise therapy of solid tumors

Y Zhang, W Chen, Y Fang, X Zhang… - Journal of the American …, 2021 - ACS Publications
Taking advantage of cancer cells' endogenous characters, the responsive activation of DNA
nanomachines has achieved great success in tumor therapy. Combining with extra stimuli …

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

R Liu, L He, Y Hu, Z Luo, J Zhang - Chemical Science, 2020 - pubs.rsc.org
Rapid and accurate diagnosis of COVID-19 plays an essential role in the current epidemic
prevention and control. Despite the promise of nucleic acid and antibody tests, there is still a …

Equipping natural killer cells with specific targeting and checkpoint blocking aptamers for enhanced adoptive immunotherapy in solid tumors

D Zhang, Y Zheng, Z Lin, X Liu, J Li… - Angewandte …, 2020 - Wiley Online Library
Herein, we propose an aptamer‐equipping strategy to generate specific, universal and
permeable (SUPER) NK cells for enhanced immunotherapy in solid tumors. NK cells were …

Three-dimensional DNA nanostructures to improve the hyperbranched hybridization chain reaction

J Wang, DX Wang, JY Ma, YX Wang, DM Kong - Chemical Science, 2019 - pubs.rsc.org
Nonenzymatic nucleic acid amplification techniques (eg the hybridization chain reaction,
HCR) have shown promising potential for amplified detection of biomarkers. However, the …

Integrating DNA nanotechnology with aptamers for biological and biomedical applications

Z Huang, L Qiu, T Zhang, W Tan - Matter, 2021 - cell.com
In addition to critical biological roles, DNA is also considered an excellent engineering
material with unique characteristics of high programmability and addressability. Recent …

Simultaneous visualization of dual intercellular signal transductions via SERS imaging of membrane proteins dimerization on single cells

C Dong, X Fang, J Xiong, J Zhang, H Gan, C Song… - ACS …, 2022 - ACS Publications
The visualization of protein dimerization on live cells is an urgent need and of vital
importance for facile monitoring the signal transduction during intercellular communication …