Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Once it became clear that inflammation takes place in the modulation of different
degenerative disease including neurodegenerative, cardiovascular, diabetes and cancer …

Aims This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and
TRPM8 channels in human systems at the transcriptional level. Main methods Using the …

Abstract Background and Purpose Antagonists of TRPV1 that inhibit all activation modes
cause hyperthermia, hampering their medical use as novel analgesics. TRPV1 antagonists …

Progressive articular surface degradation during arthritis causes ongoing pain and
hyperalgesia that lead to the development of functional disability. TRPA1 channel …

Marine molluscs are of enormous scientific interest due to their astonishing diversity in terms
of their size, shape, habitat, behaviour, and ecological roles. The phylum Mollusca is the …

Neuropathic pain is characterised by periodic or continuous hyperalgesia, numbness, or
allodynia, and results from insults to the somatosensory nervous system. Peripheral nerve …

Introduction The efficacy of trypsin-chymotrypsin in postoperative pain management
following single-visit root canal treatment of teeth with symptomatic irreversible pulpitis was …

Opioids are an important therapeutic option for severe resistant chronic pain but, in the
absence of proper oversight, their use has risks. The level of prescription opioid …

Sensory neurons embedded in muscle tissue that initiate pain sensations, ie, nociceptors,
are temporarily sensitized by inflammatory mediators during musculoskeletal trauma. These …