Epigenetics of early cardiometabolic disease: mechanisms and precision medicine

AA Baccarelli, J Ordovás - Circulation Research, 2023 - Am Heart Assoc
Epigenetics has transformed our understanding of the molecular basis of complex diseases,
including cardiovascular and metabolic disorders. This review offers a comprehensive …

[HTML][HTML] Exploring the Involvement of Gut Microbiota in Cancer Therapy-Induced Cardiotoxicity

Kunika, N Frey, AY Rangrez - International Journal of Molecular Sciences, 2023 - mdpi.com
Trillions of microbes in the human intestinal tract, including bacteria, viruses, fungi, and
protozoa, are collectively referred to as the gut microbiome. Recent technological …

Surface Grafted N‐Oxides have Low‐Fouling and Antibacterial Properties

N Burmeister, E Zorn, A Farooq… - Advanced Materials …, 2023 - Wiley Online Library
Low‐fouling materials are often generated by surface zwitterionization with polymers. In this
context, poly‐N‐oxides have recently attracted considerable attention as biomimetic stealth …

[HTML][HTML] Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor

H Xie, N Yang, C Yu, L Lu - Cellular & Molecular Biology Letters, 2024 - Springer
Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that
responds to pollutants. Subsequent research has revealed that AhR recognizes multiple …

[HTML][HTML] Association between intestinal microecological changes and Atherothrombosis

X Zhuo, H Luo, R Lei, X Lou, J Bian, J Guo, H Luo… - Microorganisms, 2023 - mdpi.com
Atherosclerosis (AS) is a chronic inflammatory disease of large-and medium-sized arteries
that causes ischemic heart disease, strokes, and peripheral vascular disease, collectively …

Potential impact of trained innate immunity on the pathophysiology of metabolic dysfunction-associated fatty liver disease

J Kountouras, E Kazakos, SA Polyzos… - Clinical …, 2023 - Elsevier
Metabolic dysfunction-associated fatty liver disease (MAFLD) occurs in a low-grade
inflammatory milieu dependent on highly complex networks that span well-beyond the …

Medicinal Chemistry of Drugs with N-Oxide Functionalities

M Kobus, T Friedrich, E Zorn… - Journal of Medicinal …, 2024 - ACS Publications
Molecules with N-oxide functionalities are omnipresent in nature and play an important role
in Medicinal Chemistry. They are synthetic or biosynthetic intermediates, prodrugs, drugs, or …

Digestive dynamics: Unveiling interplay between the gut microbiota and the liver in macronutrient metabolism and hepatic metabolic health

MR Kandalgaonkar, V Kumar… - Physiological …, 2024 - Wiley Online Library
Although the liver is the largest metabolic organ in the body, it is not alone in functionality
and is assisted by “an organ inside an organ,” the gut microbiota. This review attempts to …

[HTML][HTML] Quantification of Trimethylamine-N-Oxide and Trimethylamine in Fish Oils for Human Consumption

D Dörfel, S Rohn, E Jantzen - Molecules, 2024 - mdpi.com
Supplementing fish oil is one of the strategies to reduce the risk of cardiovascular disease,
the leading cause of death around the world. Contradictorily, fish oil may also contain …

Contributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

RA León-Letelier, R Dou, J Vykoukal… - Clinical …, 2024 - academic.oup.com
Background Increasing evidence implicates microbiome involvement in the development
and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of …