Tobacco use is a major public health problem worldwide. Tobacco-related cancers cause
millions of deaths annually. Although several tobacco agents play a role in the development …

O6-Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the pre-
mutagenic, pre-carcinogenic and pre-toxic DNA damage O6-methylguanine. It also repairs …

Tobacco smoke (TS) contains numerous cancer-causing agents, with polycyclic aromatic
hydrocarbons (PAHs) and nitrosamines being most frequently cited as the major TS human …

Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke
and can arise endogenously. More recently, nitrosamines have been detected as impurities …

Viral hepatitis in all its forms is a major public health problem throughout the world, affecting
several hundreds of millions of people. Viral hepatitis is a cause of considerable morbidity …

DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and
repair of smoking‐related DNA adducts remains particularly challenging as both smokers …

Previous studies have shown that replicative bacterial and viral DNA polymerases are able
to bypass the mutagenic lesions O 6-methyl and-benzyl (Bz) G. Recombinant human …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
tobacco products, and exposure to it is likely one of the factors contributing to the …

The formation of deoxyribonucleic acid (DNA) adducts can have important and adverse
consequences for cellular and whole organism function. Available methods for identification …

The tobacco-specific nitrosamines N '-nitrosonornicotine (NNN, 1) and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …