Chronic stress is encountered in our everyday life and is thought to contribute to a number of
diseases. Many of these stress-related disorders display a sex bias. Because glucocorticoid …

Male house mice excrete large amounts of protein in their urinary scent marks, mainly
composed of Major Urinary Proteins (MUPs), and these lipocalins function as pheromones …

This review briefly addresses the history of the discovery and elucidation of the three cloned
11β-hydroxysteroid dehydrogenase (11βHSD) enzymes in the human, 11βHSD1, 11βHSD2 …

Most mammalian physiology is orchestrated by the circadian clock, including drug transport
and metabolism. As a result, efficacy and toxicity of many drugs are influenced by the timing …

Encoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports
glucocorticoids and regulates their access to cells. We determined how CBG influences …

T Helper 17 (Th17) cells are adaptive immune cells that play myriad roles in the body.
Immune–endocrine interactions are vital in endocrine organs during pathological states …

The liver is a vital organ that sustains multiple functions beneficial for the whole organism. It
is sexually dimorphic, presenting sex-biased gene expression with implications for the …

Glucocorticoids (GCs) are critical modulators of the immune system. The hypothalamic-
pituitary-adrenal (HPA) axis regulates circulating GC levels and is stimulated by endotoxins …

Produced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma
distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone …

11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) is a drug target to attenuate adverse
effects of chronic glucocorticoid excess. It catalyses intracellular regeneration of active …