Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Alzheimer's disease (AD) is a common neurodegenerative disorder in the elderly
characterized by memory loss and cognitive dysfunction. The pathogenesis of AD is …

Protein kinases (PKs) have emerged as one of the most intensively investigated drug targets
in current pharmacological research, with indications ranging from oncology to …

Alzheimer's disease (AD) belongs to a group of neurodegenerative diseases collectively
designated as “tauopathies”, because they are characterized by the aggregation of …

Tau is a microtubule-associated-protein that is sorted into neuronal axons in physiological
conditions. In Alzheimer disease (AD) and other tauopathies, Tau sorting mechanisms fail …

Hyperphosphorylation and aggregation of the microtubule‐associated protein tau in brain,
are pathological hallmarks of a large family of neurodegenerative disorders, named …

Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …

Tauopathies are neurodegenerative diseases characterized by the pathological
accumulation of microtubule-associated protein tau (MAPT) in the form of neurofibrillary …

Alzheimer's disease (AD) is one of the most frequently diagnosed neurodegenerative
disorders worldwide and poses a major challenge for both affected individuals and their …

Tauopathies are neurodegenerative diseases that are characterized by accumulation of
hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. Protein …