G protein-coupled receptors (GPCRs) are cell surface receptors that mediate the function of
extracellular ligands. Understanding how GPCRs work at the molecular level has important …

Non-alcoholic fatty liver disease (NAFLD) is a multifaceted clinicopathological syndrome
characterised by excessive hepatic lipid accumulation that causes steatosis, excluding …

Introduction Non-alcoholic fatty liver disease (NAFLD) with obesity seriously threats public
health. Our previous studies showed that dark tea had more potential on regulating lipid …

Nuclear factor erythroid 2‐related factor 2 (Nrf2) is reportedly involved in hepatic lipid
metabolism, but the results are contradictory, and the underlying mechanism remains …

Aim Previously, we revealed a crucial role of 5-HT degradation system (5DS), consisting of 5-
HT2A receptor (5-HT2AR), 5-HT synthases and monoamine oxidase A (MAO-A), in ischemia …

Aim: Previously, we found that diabetes-related liver dysfunction is due to activation of the 5-
HT 2A receptor (5-HT 2A R) and increased synthesis and degradation of 5-HT. Here, we …

hydroxytryptamine (5-HT) is involved in the pathological processes of several liver diseases.
Acute liver injury underlies the development of many liver diseases, but the mechanism …

Comorbidity between diabetes mellitus (DM) and depression, two chronic and devastating
diseases spreading worldwide, has been confirmed by a large body of epidemiological and …

As a widely used anticancer drug in the clinic, cisplatin has obvious side effects, especially
nephrotoxicity. Previous studies have suggested that the accumulation of intracellular …

Abstract Serotonin (5-HT) produced by enterochromaffin (EC) cells in the digestive tract is
crucial for maintaining gut function and homeostasis. Nutritional and non-nutritional stimuli …