RNA-binding proteins and cancer metastasis

S Wang, Z Sun, Z Lei, HT Zhang - Seminars in cancer biology, 2022 - Elsevier
RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer

W Li, X Deng, J Chen - Seminars in cancer biology, 2022 - Elsevier
ABSTRACT RNA-binding proteins (RBPs) are key players in cellular physiology through
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …

RNA-binding proteins in cancer: functional and therapeutic perspectives

D Kang, Y Lee, JS Lee - Cancers, 2020 - mdpi.com
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …

[HTML][HTML] Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination

AM Yu, MJ Tu - Pharmacology & therapeutics, 2022 - Elsevier
The concepts of developing RNAs as new molecular entities for therapies have arisen again
and again since the discoveries of antisense RNAs, direct RNA-protein interactions …

[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer

M Mehta, R Raguraman, R Ramesh… - Advanced drug delivery …, 2022 - Elsevier
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells

J Lv, Y Zhou, N Zhou, Z Wang, J Chen… - Science translational …, 2023 - science.org
Weak immunogenicity of tumor cells is a root cause for the ultimate failure of
immunosurveillance and immunotherapy. Although tumor evolution can be shaped by …

RNA-binding proteins as important regulators of long non-coding RNAs in cancer

K Jonas, GA Calin, M Pichler - International journal of molecular sciences, 2020 - mdpi.com
The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among
which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile …

First small-molecule inhibitors targeting the RNA-binding protein IGF2BP2/IMP2 for cancer therapy

C Dahlem, A Abuhaliema, SM Kessler… - ACS chemical …, 2022 - ACS Publications
The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …

RNA-binding proteins and their role in kidney disease

L Seufert, T Benzing, M Ignarski… - Nature Reviews …, 2022 - nature.com
RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

RNA-binding proteins hold key roles in function, dysfunction, and disease

S Kelaini, C Chan, VA Cornelius, A Margariti - Biology, 2021 - mdpi.com
Simple Summary Chronic hyperglycemia manifests in a variety of different micro-and
macrovascular disorders such as diabetes mellitus and cardiovascular disease and has …