[HTML][HTML] Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets

PA Castro, I Pinto-Borguero, GE Yévenes… - Frontiers in …, 2022 - frontiersin.org
The main strategy for the treatment of epilepsy is the use of pharmacological agents known
as antiseizure medication (ASM). These drugs control the seizure onset and improves the …

The evolution of antiseizure medication therapy selection in adults: Is artificial intelligence-assisted antiseizure medication selection ready for prime time?

CL Gunasekera, JI Sirven… - Journal of Central …, 2023 - journals.sagepub.com
Antiseizure medications (ASMs) are the mainstay of symptomatic epilepsy treatment. The
primary goal of pharmacotherapy with ASMs in epilepsy is to achieve complete seizure …

[HTML][HTML] Increasing use of newer antiseizure medication during pregnancy: An observational study with special focus on lacosamide

M Hoeltzenbein, S Slimi, AK Fietz, R Stegherr… - Seizure, 2023 - Elsevier
Introduction Epilepsy is a common neurological disease requiring long-term therapy also
during pregnancy. Most studies on pregnancy outcomes in women with epilepsy are based …

[HTML][HTML] Intravenous topiramate for seizure emergencies–first in human case report

L Apostolakopoulou, PB Varela, F Rossini… - Epilepsy & Behavior, 2023 - Elsevier
Topiramate (TPM) is widely used in focal and generalized epilepsies. It is commercially
available as tablets and sprinkles capsules for oral treatment. Previous studies comparing …

Levetiracetam vs lamotrigine as first-line antiseizure medication in female patients with idiopathic generalized epilepsy

EC Irelli, E Cocchi, A Morano, J Gesche… - JAMA …, 2023 - jamanetwork.com
Importance After the recent limitations to prescribing valproate, many studies have
highlighted the challenging management of female patients of reproductive age with …

Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo

L Lesné, C Desdoits-Lethimonier, E Hug… - Toxicological …, 2023 - academic.oup.com
Valproic acid (VPA) has long been the most widely used antiepileptic drug (AED) for the
treatment of epilepsy, bipolar psychiatric disorders, and migraine. However, long-term VPA …

Perampanel for the treatment of people with idiopathic generalized epilepsy in clinical practice

E Trinka, T Alsaadi, H Goji, T Maehara, S Takahashi… - …, 2023 - Wiley Online Library
Objective This study was undertaken to evaluate perampanel (PER) when used under real‐
world conditions to treat people with idiopathic generalized epilepsy (IGE) included in the …

Depression treatment in pregnancy: is it safe, or is it not?

V Gallitelli, R Franco, S Guidi, L Puri… - International journal of …, 2024 - mdpi.com
Prenatal depression carries substantial risks for maternal and fetal health and increases
susceptibility to postpartum depression. Untreated depression in pregnancy is correlated …

The impact of pregnancy-related hormonal and physiological changes on antiseizure medications: expert perspective

D Li, S Franco, PB Pennell - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Epilepsy is a disorder of recurrent, unprovoked seizures affecting approximately
15 million individuals of childbearing potential worldwide. Patients with epilepsy rely on …

[HTML][HTML] Presynaptic antiseizure medications-basic mechanisms and clues for their rational combinations

EK Czapińska-Ciepiela, J Łuszczki, P Czapiński… - Pharmacological …, 2024 - Springer
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the
presynaptic release machinery. Of them, levetiracetam and brivaracetam show a high affinity …