Occult lymph node metastasis (OLNM) is one of the main causes of regional recurrence in
inoperable N0 non‐small cell lung cancer (NSCLC) patients following stereotactic ablation …

A central problem in cancer immunotherapy with immune checkpoint blockade (ICB) is the
development of resistance, which affects 50% of patients with metastatic melanoma 1, 2. T …

The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of
the T cells. Upon antigen exposure, T cells undergo metabolic reprogramming, leading to …

The therapeutic modes of cancers have been profoundly renovated by immunotherapies,
which have shown extraordinary treating efficacy in certain tumor entities. However, the …

Immunological priming–either in the context of prior infection or vaccination–elicits protective
responses against subsequent Mycobacterium tuberculosis (Mtb) infection. However, the …

Persistent antigen exposure results in the differentiation of functionally impaired, also termed
exhausted, T cells which are maintained by a distinct population of precursors of exhausted …

Ageing profoundly impacts T cell immunity, compromising vaccine responses, susceptibility
to infections, and immunosurveillance. Mechanisms of T cell ageing involve cell-intrinsic …

摘要目的: 探索CD39 分子(编码基因ENTPD1) 在原发性肝细胞肝癌(Hepatocellular carcinoma,
HCC) 中的表达, 临床意义及其与HCC 中免疫浸润和T 细胞耗竭的相关性. 方法: TIMER, GEPIA …

Cancers have been interpreted either as somatic evolution of cheater cells that escape
replication regulation or alternatively as non-healing wounds. Both the interpretations have …

Over the past several years, four regimens incorporating immune checkpoint inhibitors have
become widely used in the front-line setting to treat metastatic clear cell renal cell …