The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Drug development has been a principal driving force in the rapid maturation of the field of
medicinal chemistry during the past several decades. During this period, the intriguing and …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

Presently cancer is a grave health issue with predominance beyond restrictions. It can affect
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …

Long noncoding RNAs (lncRNAs) are implicated in renal cell carcinoma (RCC), but remain
largely unclear. Using publicly available transcriptome sequencing data from renal cancer …

Cancer is a large group of diseases that can affect any organ or body tissue due to the
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …

T790M mutation is the most common mechanism of acquired resistance to first-generation
epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). To overcome this …

Epidermal growth factor receptor (EGFR) signaling pathway has been previously
investigated for its significant role in the progression of different types of malignant tumors …

Tyrosine protein kinases (TKs) have been proved to play substantial roles on many cellular
processes and their overexpression tend to be found in various types of cancers. Therefore …

A new series of 4-anilinoquinazolines with C-6 ureido and thioureido side chains and
various substituents at the C-4 anilino moiety was designed, synthesized and evaluated as …