Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy
Z Iqbal, S Azmi, R Yadav, M Ferdousi, M Kumar… - Clinical …, 2018 - Elsevier
Purpose Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy
worldwide, and its prevalence increases with the duration of diabetes. It affects …
worldwide, and its prevalence increases with the duration of diabetes. It affects …
Current understanding of the mixed pain concept: a brief narrative review
R Freynhagen, HA Parada… - … medical research and …, 2019 - Taylor & Francis
Despite having been referenced in the literature for over a decade, the term “mixed pain”
has never been formally defined. The strict binary classification of pain as being either …
has never been formally defined. The strict binary classification of pain as being either …
Neuropathic pain: mechanism-based therapeutics
K Bannister, J Sachau, R Baron… - Annual Review of …, 2020 - annualreviews.org
Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …
Advances in understanding nociception and neuropathic pain
E St. John Smith - Journal of neurology, 2018 - Springer
Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …
Central sensitization: clinical utility of a physiological concept for the International Statistical Classification of Diseases and Related Health Problems and for …
RD Treede, U Hoheisel, D Wang, W Magerl - Pain, 2022 - journals.lww.com
The nociceptive system adapts readily to the varying needs of a warning system for
maintenance of bodily integrity. It often decreases its sensitivity upon continuous …
maintenance of bodily integrity. It often decreases its sensitivity upon continuous …
Maximizing treatment efficacy through patient stratification in neuropathic pain trials
R Baron, AH Dickenson, M Calvo, SD Dib-Hajj… - Nature Reviews …, 2023 - nature.com
Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …
multiple pathophysiological mechanisms and the development of promising therapeutic …
Peripheral voltage-gated cation channels in neuropathic pain and their potential as therapeutic targets
SRA Alles, PA Smith - Frontiers in Pain Research, 2021 - frontiersin.org
The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …
neurons is imperative for the development and persistence of many forms of neuropathic …
[HTML][HTML] Advances and challenges in neuropathic pain: a narrative review and future directions
Over the past few decades, substantial advances have been made in neuropathic pain
clinical research. An updated definition and classification have been agreed. Validated …
clinical research. An updated definition and classification have been agreed. Validated …
The role of quantitative sensory testing in the prediction of chronic pain
RD Treede - Pain, 2019 - journals.lww.com
Quantitative sensory testing (QST) is a formal variant of a time-honoured clinical
examination technique in neurology, the sensory examination. Prototypical QST profiles …
examination technique in neurology, the sensory examination. Prototypical QST profiles …