Autophagy is a complex process involved in several cell activities, including tissue growth,
differentiation, metabolic modulation, and cancer development. In prostate cancer …

Urological cancers include bladder, prostate and renal cancers that can cause death in
males and females. Patients with urological cancers are mainly diagnosed at an advanced …

Colorectal cancer (CRC) is the most common malignancy-related cause of death worldwide.
The prognosis of CRC patients is strongly correlated with elevated plasma copper. The …

In order to proliferate in unfavourable conditions, cancer cells can take advantage of the
naturally occurring endoplasmic reticulum-associated unfolded protein response (UPR) via …

The c-Myc signaling is a new emerging target in cancer therapy. Activation of c-Myc
signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can …

Background This study aims to examine the associations between metformin use concurrent
with androgen deprivation therapy (ADT) and mortality risks in Asian, diabetic patients with …

Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in
the degradation and recycling of cellular components. There is growing evidence that …

Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been
described by clinical studies showing reduced risk of cancer development in T2DM patients …

The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge
that demands the development of effective new drugs. Phenformin has been shown to …

Background Autophagy is a well-conserved catabolic process that plays a key role in cell
homeostasis. In the prostate, defective autophagy has been implicated in the genesis and …