Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Introduction Individualizing antibiotic therapy is paramount to improve clinical outcomes
while minimizing the risk of toxicity and antimicrobial therapy. β-lactam antibiotics are …

Introduction Severe burn injury involves widespread skin and tissue damage leading to
systemic inflammation, hypermetabolism and multi‐organ failure. The hypermetabolic phase …

In recent years, augmented renal clearance (ARC), in which renal function is excessively
enhanced, has been reported, and its influence on β-lactam antibiotics has been …

Objectives The aim of this study was to evaluate different dosage regimens of meropenem in
elderly patients in relation with renal function using a population pharmacokinetic (popPK) …

The number of pharmacokinetic (PK) models of meropenem is increasing. However, the
daily role of these PK models in the clinic remains unclear, especially for critically ill patients …

Introduction Meropenem is a carbapenem antibiotic, which has demonstrated excellent
antimicrobial activity against gram-negative clinical isolates. It is also commonly used in …

Objectives To investigate the effect of double-, single-and none-carbapenem-containing
antimicrobial regimens in the treatment of patients with carbapenem-resistant …

Study objective High‐dose continuous venovenous hemofiltration (CVVH) is a continuous
renal replacement therapy (CRRT) used frequently in patients with burns. However …