Abstract The multifunctional Survival Motor Neuron (SMN) protein is required for the survival
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …

Seed dormancy has played a significant role in adaptation and evolution of seed plants.
While its biological significance is clear, molecular mechanisms underlying seed dormancy …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Nucleophilic amino acids make important contributions to protein function, including
performing key roles in catalysis and serving as sites for post-translational modification …

Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in
regulating gene expression and maintaining cellular identity. Recently, TET1 was found to …

Innate immune responses are triggered by the activation of pattern-recognition receptors
(PRRs). The Arabidopsis PRR FLAGELLIN-SENSING 2 (FLS2) senses bacterial flagellin …

Normal differentiation and induced reprogramming require the activation of target cell
programs and silencing of donor cell programs,. In reprogramming, the same factors are …

A crucial aspect of development, homeostasis and prevention of disease is the strict
maintenance of patterns of gene repression. Gene repression is largely achieved by the …

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert
profound effects on development, and complement cancer chemotherapeutic regimens. All …

Circadian rhythms in mammals are generated by a feedback loop in which the three
PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the …