The regulation of transcription of the human immunodeficiency virus (HIV) is a complex
event that requires the cooperative action of both viral and cellular components. In latently …

Long-lived latent HIV-infected cells lead to the rebound of virus replication following
antiretroviral treatment interruption and present a major barrier to eliminating HIV infection …

The transcription factor LSF (Late SV40 Factor), also known as TFCP2, belongs to the
LSF/CP2 family related to Grainyhead family of proteins and is involved in many biological …

Background Novel therapeutic approaches are needed to attack persistent proviral human
immunodeficiency type 1 (HIV-1) infection. Hexamethylbisacetamide (HMBA), a hybrid …

The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing
coronavirus disease 2019 (COVID-19), resulting in acute respiratory disease, is a worldwide …

The HIV-1 LTR is regulated by multiple signaling pathways responsive to T cell activation. In
this study, we have examined the contribution of the MAPK, calcineurin-NFAT and TNFα-NF …

The multifunctional transcription factor Yin Yang 1 (YY1) is a complex protein that has been
shown to play pivotal roles in development, differentiation, cellular proliferation and …

Cell cycle progression in mammalian cells from G1 into S phase requires sensing and
integration of multiple inputs, in order to determine whether to continue to cellular DNA …

The Nef protein of HIV-1 is a key promoter of disease progression, owing to its dramatic yet
ill-defined impact on viral replication. Previously, we have shown that Nef enhances …

Transcription factor LSF is required for progression from quiescence through the cell cycle,
regulating thymidylate synthase (Tyms) expression at the G1/S boundary. Given the constant …