Association of the clinical and genetic factors with superior vena cava arrhythmogenicity in atrial fibrillation

Y Ebana, J Nitta, Y Takahashi, S Miyazaki… - Circulation …, 2017 - jstage.jst.go.jp
Background: Atrial fibrillation (AF) can be initiated from arrhythmogenic foci within the
muscular sleeves that extend not only into the pulmonary veins but also into both vena …

Chromosome 4q25 variants and recurrence after second-generation cryoballoon ablation in patients with paroxysmal atrial fibrillation

S Miyazaki, Y Ebana, L Liu, H Nakamura… - International journal of …, 2017 - Elsevier
Background Chromosome 4q25 single-nucleotide polymorphisms (SNPs) are associated
with atrial fibrillation (AF) recurrence after radiofrequency catheter ablation, however the …

The burgeoning field of ablatogenomics

JD Roberts, GM Marcus - Circulation: Arrhythmia and …, 2015 - Am Heart Assoc
Although clinical practice patterns were similar among the 3 sites, there were some notable
differences. The additional placement of empirical left atrial linear lesions, at the discretion of …

Ablation and antiarrhythmic drug effects on PITX2+/− deficient atrial fibrillation: A computational modeling study

Z Jin, I Hwang, B Lim, OS Kwon, JW Park… - Frontiers in …, 2022 - frontiersin.org
Introduction Atrial fibrillation (AF) is a heritable disease, and the paired-like homeodomain
transcription factor 2 (PITX2) gene is highly associated with AF. We explored the differences …

Genetics of Atrial Fibrilation: In search of novel therapeutic targets

E Lozano-Velasco, C Garcia-Padilla… - … Current Drug Targets …, 2019 - ingentaconnect.com
Atrial fibrillation (AF) is the most frequent arrhythmogenic disease in humans, ranging from
2% in the general population and rising up to 10-12% in 80+ years. Genetic analyses of AF …

Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation

JD Roberts, TA Dewland, DV Glidden, TJ Hoffmann… - American heart …, 2016 - Elsevier
Background Renin-angiotensin system (RAS) inhibition via angiotensin-converting enzyme
inhibitors and angiotensin II receptor blockers may reduce the risk of developing atrial …

Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations

M Hong, Y Ebana, J Shim, EK Choi… - European Journal of …, 2021 - Wiley Online Library
Abstract Background In European ancestry, 111 genetic loci were identified as associated
with atrial fibrillation (AF). We explored the reproducibility of those single nucleotide …

Chromosome 4q25 variant rs6817105 bring sinus node dysfunction and left atrial enlargement

S Tomomori, Y Nakano, H Ochi, Y Onohara… - Scientific Reports, 2018 - nature.com
Genome-wide association studies have reported a strong association of the single
nucleotide polymorphism (SNP) rs6817105 (T> C) on chromosome 4q25 with atrial …

Association of ZFHX3 Genetic Polymorphisms and Extra-Pulmonary Vein Triggers in Patients With Atrial Fibrillation Who Underwent Catheter Ablation

I Hwang, OS Kwon, M Hong, SY Yang, JW Park… - Frontiers in …, 2022 - frontiersin.org
Background: The ZFHX3 gene (16q22) is the second most highly associated gene with atrial
fibrillation (AF) and is related to inflammation and fibrosis. We hypothesized that ZFHX3 is …

Signal-averaged P wave area increases during respiratory events in patients with paroxysmal atrial fibrillation and obstructive sleep apnea

K Monahan, E Hodges, A Agrawal, R Upender… - Sleep and …, 2019 - Springer
Purpose P wave characteristics change during simulated apneic events in individuals with
atrial fibrillation (AF). This study sought to assess whether similar changes occur during …