There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Advances in fluorescent calcium indicating dyes over the past decade have identified
calcium signaling as the tool by which astrocytes communicate among themselves and with …

New Findings• What is the topic of this review? This is a personal historical review about the
discovery and the main conceptual advances leading to our current understanding of …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

Physiological evidence supporting the role of the adenine nucleotide, ATP 1 (Figure 1), as a
neurotransmitter was first summarized in detail in 1972, 1 representing the basis of …

A genetic polymorphism in the human gene encoding connexin37 (CX37, encoded by
GJA4, also known as CX37) has been reported as a potential prognostic marker for …

The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor
subtypes is described. This is followed by a summary of what is known of the distribution and …

ATP, besides an intracellular energy source, is an agonist when applied to a variety of
different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are …