The majority of prostate cancers (PCa) express high levels of androgen receptor (AR) and
are dependent for their growth on testosterone produced by the testes, which is reduced in …

PURPOSE To review the most important recent advances in clinical trials and biologic
studies within the growing field of chemoprevention. METHODS The most critical methods …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Recently, many therapeutic agents for prostate cancer have been approved that target the
androgen receptor and/or the prostate tumor microenvironment. Each of these therapies has …

The androgen receptor (AR) mediates the growth of benign and malignant prostate in
response to dihydrotestosterone (DHT). In patients undergoing androgen deprivation …

The sexual differentiation paradigm contends that the female pattern of the reproductive
system is established by default because the male reproductive tracts (Wolffian ducts) in the …

Abstract Introduction Panax notoginseng (Burkill) FH commonly referred to as Sanqi, is a
Chinese herb that has long been used to treat various conditions including blood disorders …

Novel coronavirus first appeared in Wuhan, China, in December 2019, and it speedily
expanded globally. Some medications which are used to treat other diseases seem to be …

Abstract Background Coronavirus Disease 2019 (COVID-19) is a multi-systemic infection
caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that …

Purpose Ligand-mediated activation of the androgen receptor (AR) is critical for prostate
cancer (PCa) survival and proliferation. The failure to completely ablate tissue androgens …