Zinc (Zn) is an essential trace mineral that regulates the expression and activation of
biological molecules such as transcription factors, enzymes, adapters, channels, and growth …

GH insensitivity (GHI) presents in childhood as growth failure and in its severe form is
associated with dysmorphic and metabolic abnormalities. GHI may be caused by genetic …

We have previously shown that familial septo-optic dysplasia (SOD), a syndromic form of
congenital hypopituitarism involving optic nerve hypoplasia and agenesis of midline brain …

Aberrant zinc (Zn) homeostasis is associated with abnormal control of mammalian growth,
although the molecular mechanisms of Zn's roles in regulating systemic growth remain to be …

The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

Defects in pituitary gland organogenesis are sometimes associated with congenital
anomalies that affect head development. Lesions in transcription factors and signaling …

Mutations in the PROP1 transcription factor gene lead to reduced production of thyrotropin,
GH, prolactin, and gonadotropins as well as to pituitary hypoplasia in adult humans and …

In GH-deficient children showing ectopic posterior pituitary hyperintense signal (EPP), the
anatomical details of the pituitary-hypothalamic region and the relationship between the …

Zinc (Zn) is an essential trace element that is vital in a wide range of cellular machineries
because of its effect on the expression and activity of various transcription factors and …

Deficiencies in the homeobox transcription factors LHX4 and PROP1 cause pituitary
hormone deficiency in both humans and mice. Lhx4 and Prop1 mutants exhibit severe …