Although acute promyelocytic leukemia (APL) is one of the most characterized forms of
acute myeloid leukemia (AML), the molecular mechanisms involved in the development and …

The majority of patients with acute promyelocytic leukemia (APL) manifest the t (15; 17)(q24.
1; q21. 2) translocation; however, a minor but significant proportion of patients with APL …

Anaplastic large cell lymphomas (ALCLs) are CD30-positive T-cell non-Hodgkin lymphomas
broadly segregated into ALK-positive and ALK-negative types. Although ALK-positive …

Context Whole-genome sequencing is becoming increasingly available for research
purposes, but it has not yet been routinely used for clinical diagnosis. Objective To …

The t (15; 17)(q24; q21), generating a PML-RARA fusion gene, is the hallmark of acute
promyelocytic leukemia (APL). At present, eight other genes fusing with RARA have been …

The Philadelphia chromosome was the first genetic abnormality discovered in cancer (in
1960), and it was found to be consistently associated with CML. The description of the …

The spectrum of chromosomal abnormality associated with leukemogenesis of acute
myeloid leukemia (AML) is broad and heterogeneous when compared to chronic myeloid …

We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF 2 BP 2–
RARA, in which the IRF 2 BP 2 gene showed completely new breakpoints. Bone marrow …

Once the diagnostic suspicion of acute promyelocytic leukemia (APL) has been raised,
international guidelines recommend prompt initiation of tailored therapy and supportive …

Acute promyelocytic leukemia (APL) is cytogenetically characterized by the t (15; 17)(q24;
q21), although cases without this translocation exist. These cases are referred to as “cryptic” …